The combination of letrozole and metformin has a better therapeutic effect on uterine and ovarian arteries in PCOS patients

Abstract

Methods Intervention-applied study was performed on 108 women with secondary infertility due to PCOS in Imam Reza Hospital of Kermanshah in 2016. Women were divided in two groups of 54 people, for investigating the effect of letrozole-metformin and clomiphene-metformin on ovarian and uterine arteries. Results Blood flow in the uterus and ovaries significantly increased after treatment with letrozole-metformin and clomiphenemetformin (P<0.05). However, the effect of letrozolemetformin was significantly higher than that of clomiphenemetformin on uterine and ovarian arteries Resistance Index (RI) (P<0.05).