Host Genetics and Pediatric Sepsis

A. Sapru, M. Quasney
{"title":"Host Genetics and Pediatric Sepsis","authors":"A. Sapru, M. Quasney","doi":"10.2174/1875041901104010082","DOIUrl":null,"url":null,"abstract":"Susceptibility to, and outcome from, sepsis in children is highly variable due in part to genetic variation in genes coding for components of the innate immune response. This review article will discuss evidence for the influence of host genetic variability on the susceptibility to, and outcome from, sepsis in children and adults. Polymorphisms in genes coding for proteins involved in the recognition of bacterial pathogens (TLR4, CD-14, Fc RIIa, and mannose binding lectin) and the response to bacterial pathogens (TNF- , IL-1 , IL-1 , IL-1RA, IL-6, IL-10, heat shock proteins, ACE, plasminogen activator inhibitor-1) can influence the amount or function of the protein produced in response to bacterial stimuli. Evidence is discussed suggesting that some of these genetic polymorphisms influence the susceptibility to, and outcome from, sepsis. Conclusion: Host genetic variability in the regulatory and coding regions of genes for components of the innate immune system may influence the susceptibility to and/or outcome from sepsis. The disparate results observed in many studies of polymorphisms in sepsis emphasize the need for future studies to be larger, to include the analysis of multiple polymorphisms, and to be better designed with respect to control populations in order to identify the degree of influence that genetic variability has on sepsis.","PeriodicalId":89637,"journal":{"name":"The open inflammation journal","volume":"4 1","pages":"82-100"},"PeriodicalIF":0.0000,"publicationDate":"2011-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open inflammation journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1875041901104010082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9

Abstract

Susceptibility to, and outcome from, sepsis in children is highly variable due in part to genetic variation in genes coding for components of the innate immune response. This review article will discuss evidence for the influence of host genetic variability on the susceptibility to, and outcome from, sepsis in children and adults. Polymorphisms in genes coding for proteins involved in the recognition of bacterial pathogens (TLR4, CD-14, Fc RIIa, and mannose binding lectin) and the response to bacterial pathogens (TNF- , IL-1 , IL-1 , IL-1RA, IL-6, IL-10, heat shock proteins, ACE, plasminogen activator inhibitor-1) can influence the amount or function of the protein produced in response to bacterial stimuli. Evidence is discussed suggesting that some of these genetic polymorphisms influence the susceptibility to, and outcome from, sepsis. Conclusion: Host genetic variability in the regulatory and coding regions of genes for components of the innate immune system may influence the susceptibility to and/or outcome from sepsis. The disparate results observed in many studies of polymorphisms in sepsis emphasize the need for future studies to be larger, to include the analysis of multiple polymorphisms, and to be better designed with respect to control populations in order to identify the degree of influence that genetic variability has on sepsis.
宿主遗传学与儿童败血症
儿童对败血症的易感性和结果是高度可变的,部分原因是先天免疫反应成分编码基因的遗传变异。这篇综述文章将讨论宿主遗传变异对儿童和成人败血症易感性和结果影响的证据。参与细菌病原体识别的蛋白质(TLR4、CD-14、FcRIIa和甘露糖结合凝集素)和对细菌病原体的反应(TNF-、IL-1、IL-1、IL-1RA、IL-6、IL-10、热休克蛋白、ACE、纤溶酶原激活物抑制剂-1)编码基因的多态性可以影响响应细菌刺激产生的蛋白质的数量或功能。证据表明,这些遗传多态性的一些影响易感性,并从结果,败血症讨论。结论:宿主先天免疫系统成分基因调控和编码区域的遗传变异可能影响败血症的易感性和/或结果。在许多关于脓毒症多态性的研究中观察到的不同结果强调了未来的研究需要更大的规模,包括对多种多态性的分析,以及更好地设计对照人群,以确定遗传变异对脓毒症的影响程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信