Sleep, Adenosine and Caffeine as Tools for The Early Diagnosis of Parkinson Disease

Abstract

The information that has developed regarding Parkinson's Disease (PD) allowed to understand that there is a period of this disease, perhaps at least a decade, in which the classical features of PD are not detected as such, however, there are evidence of a series of non-motor manifestations, among which are: anosmia, constipation, psychiatric disorders such as major depression, generalized anxiety, and rapid eye movement sleep behavior disorder (RBD). On the other hand the understanding of physiological mechanisms of sleep-wake cycle, have become remarkable tools to explore neurological and psychiatric disorders and complemented the information and treatments for those disorders. There is evidence that RBD can occur in half of people who will develop PD, about 10 year letter. The role of adenosine in sleep and caffeine intolerance is other aspects that are evident in the relation between PD and sleep. The detection of PD in early stages, may allow the implementation of the type of therapeutic strategies for neuroprotection. The general goal would be delay or reduce the clinical manifestations of PD in some patients.