Sleep Duration and Oxidative Stress: The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study

The open sleep journal Pub Date : 2008-03-25 DOI:10.2174/1874620900801010015

L. Charles, C. Burchfiel, D. Fekedulegn, J. Violanti, R. Browne, E. McCanlies, M. Andrew

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Abstract

Our objective was to investigate the cross-sectional association between sleep duration and biomarkers of oxi- dative stress (glutathione (GSH), glutathione peroxidase (GSH-Px), vitamin C, thiobarbituric acid reactive substances (TBARS), and trolox equivalent antioxidant capacity (TEAC)) among police officers. Standardized techniques were used to analyze biomarkers in fasting blood specimens. Mean levels of biomarkers were compared across levels of sleep dura- tion (0-4.9, 5.0-6.9, � 7.0 hours) using ANOVA. Officers' (women=44; men=69) mean age was 39.6 years. Positive trends were observed across sleep categories with mean levels of GSH and vitamin C only among women (p trend=0.156 and 0.022 respectively), with attenuation after risk-factor adjustment. Positive trends were observed for vitamin C among older officers (p trend=0.018) but not younger. No associations were observed between sleep duration and biomarkers among men. Longer sleep duration is associated with higher levels of vitamin C among policewomen and older officers. Additional studies are warranted.

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睡眠时间和氧化应激:水牛心脏代谢职业警察应激(BCOPS)研究

我们的目的是调查警察睡眠时间与氧化应激生物标志物(谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH- px)、维生素C、硫代巴比妥酸活性物质(TBARS)和trolox等效抗氧化能力(TEAC))之间的横断面关联。采用标准化技术分析空腹血液标本中的生物标志物。采用方差分析比较不同睡眠时间(0-4.9小时、5.0-6.9小时、7.0小时)的生物标志物的平均水平。军官(女性= 44;男性=69)，平均年龄39.6岁。在所有睡眠类别中，只有女性的谷胱甘肽和维生素C的平均水平呈阳性趋势(p趋势分别为0.156和0.022)，在调整风险因素后呈衰减趋势。在老年军官中，维生素C呈阳性趋势(p趋势=0.018)，而在年轻军官中则无阳性趋势。在男性中，没有观察到睡眠时间和生物标志物之间的关联。在女警察和老年警察中，较长的睡眠时间与较高的维生素C水平有关。有必要进行进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The open sleep journal

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