Kinetics of Plasmodium falciparum Gametocyte Sex Ratios: Application to the Evaluation of the Potential of Antimalarial Drugs to Influence Malaria Transmission

The open tropical medicine journal Pub Date : 2011-10-05 DOI:10.2174/1874315301104010033

G. Gbotosho, A. Sowunmi, C. Happi

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引用次数: 2

Abstract

A non-compartment pharmacokinetic model was used to evaluate the potential of antimalarial drugs to influence malaria transmission using the ratio of sex specific gametocyte half-lives male:female- the gametocyte maleness index (GMI), and the ratio of the sex specific area inscribed by the plot of gametocyte sex density versus time curves AUCmg:AUCfg- the gametocyte maleness load index (GMLI). Data on gametocyte sexes collected in children with symptomatic Plasmodium falciparum malaria who were treated with various antimalarial drugs in an endemic area were examined using the two indices. Both GMI and GMLI were positively correlated (r = 0.71, P 1 for 4- aminoquinolines and antifolates suggesting potential for increasing the chance of mosquito infectivity. By contrast, artesunate and artemisinin-based combination therapies (ACTs), artemether-lumefantrine, and artesunate-amodiaquine, and a non-ACT, amodiaquine plus sulfalene-pyrimethamine, had ratios < 1 suggesting potential for reducing the chance of mosquito infectivity. The advantages and drawbacks of using these indices as tools in assessing the influence of antimalarials on transmission potentials in endemic areas of malaria are discussed.

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恶性疟原虫配子体性别比例动力学:应用于抗疟药物影响疟疾传播潜力的评估

采用非室室药代动力学模型，利用性别特异性配子细胞半衰期雄性:雌性的比值——配子细胞雄性指数(GMI)，以及配子细胞性密度与时间曲线AUCmg:AUCfg所示的性别特异性面积的比值——配子细胞雄性负荷指数(GMLI)，评估抗疟药物对疟疾传播的影响潜力。采用这两种指标对某流行地区使用各种抗疟药物治疗的有症状的恶性疟原虫患儿配子体性别进行了分析。4-氨基喹啉类药物和抗叶酸类药物的GMI和GMLI均呈正相关(r = 0.71, P < 1)，提示其可能增加蚊虫感染的机会。相比之下，青蒿琥酯和青蒿素为基础的联合疗法(ACTs)，蒿甲醚-甲苯芳碱和青蒿琥酯-阿莫地喹，以及非act，阿莫地喹加磺胺-乙胺嘧啶的比值< 1，表明有可能降低蚊子感染的机会。讨论了使用这些指数作为评估抗疟药物对疟疾流行地区传播潜力影响的工具的优点和缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The open tropical medicine journal

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