Evaluation of Pulmonary Nodules Using the Spyglass Direct Visualization System Combined With Radial Endobronchial Ultrasound: A Clinical Feasibility Study

Q3 Medicine

Open Respiratory Medicine Journal Pub Date : 2016-11-30 DOI:10.2174/1874306401610010079

K. Godbout, S. Martel, Mathieu Simon, N. Lampron, A. Delage

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引用次数: 2

Abstract

Background: Sampling of peripheral pulmonary nodules with radial endobronchial ultrasound (p-EBUS) increases diagnostic yield of bronchoscopy. However, diagnostic yield is influenced by numerous factors. Objective: We evaluated the use of SpyGlass, a one millimeter diameter optic fiber, to obtain images of the distal mucosa and of pulmonary lesions detected with p-EBUS to determine if visual aspect of the distal mucosa was predictive of diagnosis. Methods: We prospectively recruited subjects investigated for peripheral nodules. Bronchoscopy was performed and p-EBUS was used to locate the lesion through a guide sheath. The Spyglass fiber was introduced in the sheath to obtain images of the distal bronchial mucosa. Tissue sampling was subsequently done. Results: Fifteen patients were enrolled in the study. A final diagnosis of malignancy was confirmed in 80%. All lesions could be located using p-EBUS (100%). Diagnostic sensitivity for p-EBUS was 58.3%. Distal mucosa could be imaged with SpyGlass in 14/15 patients (93.3%). Mucosal appearance was described as abnormal in 7 out of the 15 subjects. Mean SpyGlass procedure time was 6.5 minutes. No direct complication was reported. Conclusion: Spyglass can be used in combination with p-EBUS to obtain images of the distal bronchial mucosa and peripheral pulmonary nodules. More patients will be needed to confirm whether mucosal appearance can be predictive of malignancy.

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望远镜直接显像系统联合桡骨支气管超声评价肺结节的临床可行性研究

背景:桡骨支气管内超声(p-EBUS)对周围性肺结节取样可提高支气管镜检查的诊断率。然而，诊断率受到许多因素的影响。目的:我们评估使用SpyGlass，一种直径1毫米的光纤，获得远端粘膜和p-EBUS检测到的肺病变的图像，以确定远端粘膜的视觉方面是否可以预测诊断。方法:我们前瞻性地招募外周结节患者。行支气管镜检查，p-EBUS通过引导鞘定位病变。在鞘中引入望远镜纤维以获得远端支气管粘膜的图像。随后进行组织取样。结果:15例患者入组研究。80%的患者最终确诊为恶性肿瘤。p-EBUS可定位所有病变(100%)。p-EBUS的诊断敏感性为58.3%。14/15(93.3%)的患者可以使用SpyGlass成像远端粘膜。15例受试者中有7例粘膜外观异常。平均SpyGlass手术时间为6.5分钟。无直接并发症报道。结论:望远镜联合p-EBUS可获得支气管远端粘膜和肺周围结节的图像。需要更多的患者来证实粘膜外观是否可以预测恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Respiratory Medicine Journal Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Open Respiratory Medicine Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in respiratory medicine. Topics covered include: -COPD- Occupational disorders, and the role of allergens and pollutants- Asthma- Allergy- Non-invasive ventilation- Therapeutic intervention- Lung cancer- Lung infections respiratory diseases- Therapeutic interventions- Adult and paediatric medicine- Cell biology. The Open Respiratory Medicine Journal, a peer reviewed journal, is an important and reliable source of current information on important recent developments in the field. The emphasis will be on publishing quality articles rapidly and making them freely available worldwide.