Genetic Control of β -Cell Mass Homeostasis

M. M. Soundarapandian, Maria L. Nieves, R. Pasquier, Ulrika Bergstrom, M. Atkinson, B. Tyrberg
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引用次数: 1

Abstract

Control of  -cell function and mass is tightly linked to glucose homeostasis. Failing  -cells inevitably lead to diabetes. Recently, several contradictory studies have been published arguing against or in favor of various mechanisms controlling  -cell mass regulation. Here we review the literature on control of adult  -cell mass and aim to reconcile thereby the contradictions. We discuss the role of � -cell proliferation and neogenesis, both in mice and man. We also discuss the influence of genetic predisposition on  -cell mass control. We conclude that  -cell generation in the adult human and mouse likely depends on many paths to assure sufficient numbers of  -cells at any given time, thereby balancing mechanisms for negative regulation of  -cell numbers. A simple model with only one pathway does not fit the current literature.
β -细胞质量稳态的遗传调控
-细胞功能和质量的控制与葡萄糖稳态密切相关。细胞衰竭不可避免地导致糖尿病。最近,一些相互矛盾的研究已经发表,反对或赞成控制-细胞质量调节的各种机制。在此,我们回顾有关成人细胞团控制的文献,并试图以此来调和这些矛盾。我们讨论了-细胞增殖和新生的作用,在小鼠和人。我们还讨论了遗传易感性对-细胞质量控制的影响。我们得出结论,成人和小鼠的-细胞生成可能依赖于许多途径,以确保在任何给定时间有足够数量的-细胞,从而平衡-细胞数量的负调节机制。只有一条路径的简单模型不适合当前的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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