Modelling and Simulations of Collective Bio-Nanomachine Rotation in 3-D Space

IF 2.4 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Pub Date : 2023-03-11 DOI:10.1109/TMBMC.2023.3275542

Jiewen Wang;Tadashi Nakano

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Abstract

Controlling a spatio-temporal structure that groups of bio-nanomachines form is a key objective for engineering innovative applications such as artificial organs and biological robots. Our previous work aimed to create a large-scale system of bio-nanomachines and developed a collective rotational motion model to describe their behavior. The main idea in developing the model is that spinning objects are stable against perturbations, meaning that a rotating cluster of bio-nanomachines may be stable and suitable for large-scale bio-nanomachine systems to be engineered for applications. In this paper, we first extend our previous model from two-dimensions to three-dimensions. We then conduct simulation experiments using the extended model and demonstrate that a group of bio-nanomachines forms a three-dimensional cluster that continues to rotate around the central axis of the cluster. This paper makes an important step toward developing computational tools to study spatio-temporal structure formation of bio-nanomachines in three dimensions.

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三维空间中集体生物纳米机器旋转的建模与仿真

控制生物纳米机器组形成的时空结构是人工器官和生物机器人等创新应用工程的关键目标。我们之前的工作旨在创建一个大规模的生物纳米机器系统，并开发了一个集体旋转运动模型来描述它们的行为。开发该模型的主要思想是，旋转物体在扰动下是稳定的，这意味着旋转的生物纳米机器集群可能是稳定的并且适合于大规模的生物纳米机系统来设计应用。在本文中，我们首先将我们以前的模型从二维扩展到三维。然后，我们使用扩展模型进行模拟实验，并证明一组生物纳米机器形成了一个三维集群，该集群继续围绕集群的中心轴旋转。本文朝着开发三维研究生物纳米机器时空结构形成的计算工具迈出了重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Transactions on Molecular, Biological, and Multi-Scale Communications Mathematics-Modeling and Simulation

CiteScore

3.90

自引率

13.60%

发文量

期刊介绍： As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.