Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine

Abstract

Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. The prepared prodrug polymer was characterized by FTIR and 1H?NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.