INIBIDORES DA GSK-3: UMA NOVA ESTRATÉGIA PARA A REGENERAÇÃO DENTAL

Abstract

The enzyme glycogen synthase kinase 3 (GSK-3) regulates several stages in cell biochemistry and the alterations in its activity involve many diseases. Since the 1990s, GSK-3 became a target site for the development of new drugs and several inhibitors were evaluated for the treatment of pathologies, such as diabetes and Alzheimer disease. Tideglusib is a GSK-3 inhibitor for the treatment of Alzheimer disease. It has been recently demonstrated that the drug may induce the natural repair of the dental pulp through the activation of stamina cells by regenerating dental material of the damaged area. The natural regeneration process is an innovation among dental restoration techniques since it stimulates the multiplication of dental pulp cells and blocks small cavities. The role of GSK-3, its inhibitors and the effects of tideglusib in dental regeneration are investigated.