Impact of Array Length on Particle Attraction in Magnetic Drug Targeting: Investigation Using an Exponential Approximation of the Magnetic Field

IF 1.1 4区物理与天体物理 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Magnetics Letters Pub Date : 2023-01-16 DOI:10.1109/LMAG.2023.3237384

Angelika S. Thalmayer;Kilian Götz;Samuel Zeising;Georg Fischer

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引用次数: 0

Abstract

In magnetic drug targeting, special magnetic nanoparticles that carry the anticancer drug are injected into the cardiovascular system in the vicinity of the tumor and are navigated into the tumor using a magnetic field. Many researchers optimize single magnets for this purpose; however, magnetic arrays that are placed parallel to the vessel in order to increase the impact time of the magnetic force on the particles are also discussed. To the best of the authors' knowledge, the improvement by the increased impact time has not been studied in detail so far and, thus, will be addressed in this work. In this context, an artificial exponential magnetic field that approximates the field of a Halbach array and acts as an upper limit consideration is applied to different impact lengths within a predefined magnetic domain. To compare the impact of the field parameters, the total magnetic energetic effort is kept constant as a reference for studying variations of impact length. The results reveal that a longer impact length increases the attraction performance enormously. However, for the same magnetic effort, a longer impact length with a lower magnetic field strength leads to the same attraction of the particles as a shorter one with higher field strengths. Since it is easier to generate lower field strengths, the usage of arrays to realize a longer impact length is preferable.

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阵列长度对磁性药物靶向中粒子吸引力的影响：利用磁场的指数近似研究

在磁性药物靶向中，携带抗癌药物的特殊磁性纳米颗粒被注射到肿瘤附近的心血管系统中，并使用磁场导航到肿瘤中。许多研究人员为此优化了单个磁体；然而，为了增加磁力对粒子的冲击时间，还讨论了平行于容器放置的磁性阵列。据作者所知，到目前为止，还没有详细研究撞击时间增加带来的改善，因此，本工作将对此进行讨论。在这种情况下，近似于Halbach阵列的场并作为上限考虑的人工指数磁场被应用于预定义磁畴内的不同冲击长度。为了比较场参数的影响，总磁能作用力保持不变，作为研究冲击长度变化的参考。结果表明，较长的冲击长度会极大地提高吸引力。然而，对于相同的磁力，具有较低磁场强度的较长冲击长度会导致与具有较高磁场强度的较短冲击长度相同的粒子吸引力。由于更容易产生较低的场强，因此优选使用阵列来实现较长的冲击长度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Magnetics Letters PHYSICS, APPLIED-

CiteScore

2.40

自引率

0.00%

发文量

期刊介绍： IEEE Magnetics Letters is a peer-reviewed, archival journal covering the physics and engineering of magnetism, magnetic materials, applied magnetics, design and application of magnetic devices, bio-magnetics, magneto-electronics, and spin electronics. IEEE Magnetics Letters publishes short, scholarly articles of substantial current interest. IEEE Magnetics Letters is a hybrid Open Access (OA) journal. For a fee, authors have the option making their articles freely available to all, including non-subscribers. OA articles are identified as Open Access.