In Vivo Measurement of Cerebral SPIO Concentration in Nonhuman Primate Using Magnetic Particle Imaging Detector

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.1109/LMAG.2023.3281933

Hui Hui;Jiaojiao Liu;Hui Zhang;Jing Zhong;Jie He;Bo Zhang;Haoran Zhang;Qin Li;Hongjun Li;Jie Tian

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引用次数: 1

Abstract

The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. Phantom experiments were first performed to determine the sensitivity limits of the detector as a function of distance from the detector and SPIO concentration. The measured sensitivity profile was then used to reveal the most sensitive region of the detector. MPI detection was continuously performed to monitor MPI signal changes after two bolus injections of SPIOs in the rhesus macaque. We successfully developed a hand-held MPI to detect cerebral SPIO concentration changes in a living nonhuman primate. The detection limit of the MPI detector is about 125 ng iron. We reported on the in vivo measurement of cerebral SPIO concentration changes in rhesus macaque using a hand-held MPI detector. In vivo experiments showed the feasibility of the detector to sensitively measure MPI signals in a nonhuman primate brain.

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用磁粉成像检测器在体测量非人类灵长类动物脑SPIO浓度

本研究的目的是开发一种磁性粒子成像（MPI）技术，直接测量恒河猴随时间变化的大脑超顺磁性氧化铁纳米颗粒（SPIO）浓度。开发了一种手持式MPI检测器，用于监测非人类灵长类动物静息状态下驱动频率三次谐波的MPI信号变化。首先进行了体模实验，以确定检测器的灵敏度极限作为与检测器的距离和SPIO浓度的函数。然后使用测量的灵敏度分布来揭示检测器的最敏感区域。在恒河猴中连续进行MPI检测以监测两次SPIO大剂量注射后的MPI信号变化。我们成功地开发了一种手持式MPI，用于检测活体非人类灵长类动物大脑SPIO浓度的变化。MPI检测器的检测极限约为125ng铁。我们报道了使用手持MPI检测器在体内测量恒河猴大脑SPIO浓度的变化。体内实验表明，该探测器可以灵敏地测量非人类灵长类动物大脑中的MPI信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.