Time-Varying Magnetic Field to Enhance the Navigation of Magnetic Microparticles in a Bifurcated Channel

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-01-27 DOI:10.1109/LMAG.2022.3146846

Pralay Chakrabarty;Roy P. Paily

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引用次数: 1

Abstract

This letter investigates the navigation of magnetic microparticles (MMPs) in a Y-shaped microfluidic channel under the influence of an external magnetic field. The external magnetic field exerts a magnetic force on the magnetizable MMPs to steer them from the bifurcation point to the desired channel. During this process, some MMPs aggregate and stick to the channel walls, thus reducing the efficacy of the navigation process. To mitigate this problem, a time-varying magnetic field (TVMF) is applied for efficient navigation of the MMPs in the channel. The TVMF alternately switches between two modes of operation described as follows. In the first mode of operation, the TVMF is applied for a certain time duration to generate the magnetic force required for steering the MMPs to the desired outlet. The second mode of operation facilitates mitigation of the stiction and aggregation of MMPs by modulating the TVMF and time duration of operation, so as to yield a lower magnetic force in the reverse direction to that in the first mode. Extensive simulations are performed to analyze the switching time for effective steering of the MMPs using COMSOL Multiphysics. Results illustrate that the time duration between the two modes of operation should be set using a ratio of 3

$:$

1 for effective guidance of the MMPs to the correct outlet.

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时变磁场增强磁性微粒在分叉通道中的导航

这封信研究了磁性微粒（MMPs）在外部磁场影响下在Y形微流体通道中的导航。外部磁场在可磁化MMP上施加磁力，将其从分叉点引导到所需通道。在这个过程中，一些MMP聚集并粘附在通道壁上，从而降低了导航过程的效率。为了缓解这个问题，时变磁场（TVMF）被应用于信道中MMP的有效导航。TVMF在两种操作模式之间交替切换，如下所述。在第一种操作模式中，TVMF被施加一定的持续时间，以产生将MMP转向所需出口所需的磁力。第二种操作模式通过调节TVMF和操作持续时间来促进MMP的静摩擦和聚集的减轻，从而在与第一种模式相反的方向上产生较低的磁力。使用COMSOL Multiphysics进行了广泛的模拟，以分析MMP有效操纵的切换时间。结果表明，两种操作模式之间的持续时间应使用3$:$1的比率设置，以有效引导MMP到达正确的出口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.