Development and clinical application of hydrogel formulations containing papain and urea for wound healing

IF 0.6 4区医学 Q4 PHARMACOLOGY & PHARMACY

Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-05-15 DOI:10.1590/s2175-97902023e201090

Thais Menezes dos Santos, Danieli Silva Feijó de Sousa, Karina Chamma Di Piero, A. Todeschini, W. Dias, C. Oliveira, E. P. Santos, M. Monteiro, M. K. Gomes, Cristiano dos Reis Moura, Pedro Antônio Castelo Teixeira, E. Ricci-Júnior, Z. Freitas

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引用次数: 0

Abstract

Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea. In this paper, carboxypolymethylene hydrogels containing papain (2% and 10% concentrations) and urea (5% concentration) were produced. Physical-chemical stability was performed at 0, 7, 15 and 30 days at 2-8ºC, 25ºC and 40ºC, as well as the rheological aspects and proteolytic activity of papain by gel electrophoresis. Clinical efficacy of the formulations in patients with lower limb ulcers was also evaluated in a prospective, single-center, randomized, double-blind and comparative clinical trial. The results showed 7-day stability for the formulations under 25ºC, in addition to approximately 100% and 15% of protein activity for 10% and 2% papain hydrogel, respectively. The rheological profile was non-Newtonian for the 10% papain hydrogel tested. There were no significant differences regarding the mean time for healing of the lesions, although 10% papain presented a better approach to be used in all types of tissue present in the wound bed.

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含有木瓜蛋白酶和尿素的伤口愈合水凝胶配方的开发和临床应用

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来源期刊

Brazilian Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

CiteScore

1.40

自引率

0.00%

发文量

165

审稿时长

7.5 months

期刊介绍： The Brazilian Journal of Pharmaceutical Sciences accepts for publication Original Papers applicable to the fields of Pharmaceutical Sciences; Reviews and Current Comment Articles, which are published under the Scientific Editor and Associate Editors invitation to recognized experts or when they are spontaneously submitted by the authors in the form of abstracts to have their importance evaluated. A critical view of the subject with insertions of results of previous works in the field in relation to the state of art must be included; Short Communications reporting new methods and previews of works on researches of outstanding importance in which originality justify a quick publication. A maximum of 2000 words excluding tables, figures and references is an acceptable limit. One table, one figure and ten references may be added, and Book Reviews of the latest editions of books, prepared by specialists invited by the Scientific Editor and Associate Editors. Thematic Supplements as well as those related to scientific meetings can be published under the Scientific Editor and/or Associate Editors agreement.