Male carriers of HLA-C*04:01 have increased risk of cardiac injury in COVID-19

The journal of cardiovascular aging Pub Date : 2022-01-01 DOI:10.20517/jca.2022.19

P. Suwalski, Michele Violano, Melina Müller, D. Patriki, C. Thibeault, C. Quedenau, Xiaomin Wang, Zehra Karadeniz, J. Saccomanno, Jan-Moritz Doehn, R. Hübner, B. Hinzmann, H. Beer, B. Wiggli, Sandra Siemann, N. Suttorp, M. Witzenrath, S. Hippenstiel, C. Skurk, W. Poller, L. Sander, F. Kurth, Tatiana Borodina, T. Guettouche, U. Landmesser, B. Heidecker

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引用次数: 1

Abstract

Identification of factors that lead to the severe clinical course of COVID-19 is crucial for timely allocation of resources. The purpose of this study was to evaluate possible sex differences in cardiac injury associated with HLA-C*04:01. High sensitivity troponin T on admission (hs-TnTa) and maximum high sensitivity troponin T (hs-TnTmax) were used to assess for cardiac injury in patients with COVID-19 (n = 435). We tested for the association of elevated hs-TnT with HLA-C* 04:01 and evaluated for potential sex-specific differences. An association between hs-TnTa and the severity of clinical course was identified. In addition, our study revealed that hs-TnTmax was higher in men who were carriers of HLA-C*04:01 compared to men without the risk allele. Male carriers of HLA-C*04:01 with COVID-19 developed higher hs-TnTmax, suggesting a larger extent of cardiac injury. This association suggests the presence of different pathomechanisms in COVID-19 based on sex.

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男性HLA-C*04:01携带者在COVID-19中心脏损伤的风险增加

确定导致COVID-19严重临床病程的因素对于及时分配资源至关重要。本研究的目的是评估与HLA-C*04:01相关的心脏损伤可能存在的性别差异。采用入院时高敏感性肌钙蛋白T (hs-TnTa)和最高高敏感性肌钙蛋白T (hs-TnTmax)评估COVID-19患者心脏损伤(n = 435)。我们检测了hs-TnT升高与HLA-C* 04:01的关系，并评估了潜在的性别特异性差异。确定了hs-TnTa与临床病程严重程度之间的关联。此外，我们的研究显示，携带HLA-C*04:01的男性的hs-TnTmax高于没有风险等位基因的男性。男性HLA-C*04:01感染者hs-TnTmax较高，提示心脏损伤程度较大。这一关联表明，基于性别的COVID-19存在不同的病理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The journal of cardiovascular aging

CiteScore

2.40

自引率

0.00%

发文量