Akut Koroner Sendrom ile Başvuran Hastalarda Daha Önceden Düzenli Asetilsalisilik Asit Kullanımının TIMI Akımı ve Miyokardiyal Hasar Üzerine Etkileri

Abstract

The effects of previous regular use of acetylsalicylic acid on timi flow grade and myocardial hamage in patients presenting with acute coronary syndrome Objective: Cardiovascular diseases are the leading cause of death worldwide. Antiaggregant therapies have an important place in the secondary prevention of cardiovascular diseases. In this study, the effects of regular use of acetylsalicylic acid on TIMI flow grade and myocardial damage will be investigated in patients presenting with acute coronary syndrome. Methods: The patients who admitted with the clinic of acute coronary syndrome and underwent coronary angiography were included in the study, retrospectively. The patients were divided into two groups as those who used acetylsalicylic acid regularly (group 1) and those who never used acetylsalicylic acid (group 2). Demographic data, laboratory data, TIMI flow grade and troponin-I values as a marker of myocardial damage were compared between the groups. Results: 440 patients were included in the study. There were 122 patients in group 1(mean age 64.9±1.0 years; 25(20.5%) women) and 318 patients in group 2(mean age 61.0±0.7 years; 83(26.1%) women). Advanced age, hypertension, diabetes mellitus, hyperlipidemia and history of coronary artery disease were observed at a higher rate in group 1. TIMI-0 flow was observed at a significantly lower rate in patients in group 1(30.3% vs. 47.8%; p=0.004). Additionally, the maximum measured troponin values of the patients in group 1 were found significantly lower (median 5486 pg/ml vs. 15740 pg/ml; p<0.001). Conclusion: TIMI flow grades were higher and the amount of enzymatic myocardial damage was found less in patients who admitted with the clinic of acute coronary syndrome and used previously regular acetylsalicylic acid. Thus, the importance of secondary protection was emphasized once again in this study.