The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients.

S. Bashir, H. Suekit, A. Elkarib, M. A. Dafaalla, M. B. Abd Elrouf, M. D. Morsy, M. Eskandar
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引用次数: 6

Abstract

Placental hypoxia, a major component of the pathophysiology of preeclampsia, is associated with various maternal vascular and endothelial dysfunctions. The higher incidence of preeclampsia at high altitude remains incompletely explained. The aim of the present study was to investigate the effect of high altitude on some endothelial and vascular dysfunction markers in normal and preeclamptic pregnancies. Eighty pregnant women (Paras 2-4) were enrolled in this study, which included four groups (each n = 20): normal pregnancies at low altitude (NL), normal pregnancies at high altitude (NH), preeclamptic pregnancies at low altitude (PL), and preeclamptic pregnancies at high altitude (PH). In normal pregnancies at high altitude serum ET-1, plasma TXA2, and serum TNF-α levels increased significantly with a significant reduction in plasma PGI2 (66.81 ± 7.36, 122.86 ± 13.37, 102.23 ± 13.31, 191.57 ± 19.68, respectively) compared with the NL group (48.92 ± 4.58, 89.03 ± 10.67, 69.86 ± 7.97, 238.01 ± 24.55, respectively). In preeclampsia at low altitude serum ET-1, plasma TXA2, and serum TNF-α levels increased significantly with a significant reduction in plasma PGI2 (88.39 ± 9.54, 162.73 ± 15.92, 142.39 ± 15.37, 149.155 ± 15.66, respectively) compared with both NL and NH groups. High altitude significantly augmented these changes in preeclamptic patients (117.75 ± 12.96, 211.01 ± 22.69, 196.86 ± 17.64, 111.92 ± 10.74) compared with PL, NH and NL groups. In conclusion hypoxia at high altitude aggravated the disturbances in the levels of ET-1, TXA2, PGI2 and TNF-α associated with preeclampsia. This may contribute to the higher risk of preeclampsia at high altitude.
高海拔对子痫前期患者内皮和血管功能障碍指标的影响。
胎盘缺氧是子痫前期病理生理的一个重要组成部分,与母体各种血管和内皮功能障碍有关。高海拔地区子痫前期的高发病率仍未完全解释。本研究的目的是探讨高海拔对正常妊娠和子痫前期妊娠一些内皮和血管功能障碍标志物的影响。本研究共纳入80例孕妇(第2 ~ 4段),分为四组(n = 20):低海拔正常妊娠(NL)、高海拔正常妊娠(NH)、低海拔子痫前期妊娠(PL)和高海拔子痫前期妊娠(PH)。正常妊娠高原组血清ET-1、血浆TXA2、血清TNF-α水平明显升高,血浆PGI2明显降低(分别为66.81±7.36、122.86±13.37、102.23±13.31、191.57±19.68)(分别为48.92±4.58、89.03±10.67、69.86±7.97、238.01±24.55)。与NL组和NH组相比,低海拔子痫前期患者血清ET-1、血浆TXA2、血清TNF-α水平显著升高,血浆PGI2水平显著降低(分别为88.39±9.54、162.73±15.92、142.39±15.37、149.155±15.66)。与PL、NH和NL组相比,高海拔显著增加了子痫前期患者的这些变化(117.75±12.96,211.01±22.69,196.86±17.64,111.92±10.74)。由此可见,高原缺氧加重了与子痫前期相关的ET-1、TXA2、PGI2和TNF-α水平的紊乱。这可能会导致高海拔地区发生子痫前期的风险更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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6.0 months
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