SYNTHESIS OF SOME N-(BENZOTHIAZOL-2-YL)-2-(4H-(1,2,4)TRIAZOL -3- YLSULFANYL)ACETAMIDES AND THEIR ANTIMICROBIAL ACTIVITY

A. Özdemir, Z. Kaplancıklı, G. Turan-Zitouni, M. Altıntop, Fatih Demirci
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引用次数: 1

Abstract

The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide derivatives were prepared by the reaction of N-(benzothiazol-2-yl)-2-chloroacetamides with appropriate 4H-[1,2,4]triazol-2-thione. The chemical structures of the compounds were elucidated by elemental analyses, IR, 1 H-NMR, 13 C-NMR and FAB + -MS spectral data. Their antimicrobial activities against Escherichia coli (NRRL B-3008), Staphylococcus aureus ( ATCC 6538) , Pseudomonas aeruginosa ( ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) ( clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organism.
若干n -(苯并噻唑-2-基)-2-(4h -(1,2,4)三唑-3-基磺胺基)乙酰酰胺的合成及其抑菌活性
本研究的目的是合成新的苯并噻唑酰胺衍生物并研究其抗菌活性。通过N-(苯并噻唑-2-基)-2-(4H-[1,2,4]三唑-3-基磺胺基)-氯乙酰胺与适当的4H-[1,2,4]三唑-2-硫酮反应,制备了N-(苯并噻唑-2-基)-2-(4H-[1,2,4]三唑-2-硫酮)乙酰胺衍生物。化合物的化学结构通过元素分析、IR、1h - nmr、13c - nmr和FAB + -MS进行了表征。研究了它们对大肠杆菌(NRRL B-3008)、金黄色葡萄球菌(ATCC 6538)、铜绿假单胞菌(ATCC 27853)、普通变形杆菌(NRRL B-123)、鼠伤寒沙门氏菌(ATCC 13311)、耐甲氧西林金黄色葡萄球菌(MRSA)(临床分离株)、白色念珠菌(NRRL Y-12983)和假丝酵母菌(NRRL Y-12696)的抑菌活性。结果表明,所有化合物对受试菌均无活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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