Dysregulated circadian clock and aged stem cell: An inflammatory crosstalk?

Abstract

Aging occurs in response to many triggers, including cellular senescence, telomere attrition, DNA damage, organelle stress, oncogene activation and stem cell dysfunction [1]. Among these, the aged stem cell per sec can exhibit various aging hallmarks, such as increased DNA damage, dysregulated mitochondrial function, and less efficient protein recycling. Aged stem cell is a prime factor that undermines organismal homeostasis, which can facilitate numerous pathologies including cancer, neuropathy, sarcopenia and immunopathy [2].