L. Roever, E. S. Resende, A. Diniz, N. Penha-Silva, J. L. O’Connell, Fernanda Rodrigues Souza, Poliana Rodrigues Alves Duarte, L. Lopes, P. F. Gomes, H. R. Zanetti, Anaisa Silva Roerver-Borges, F. Veloso, T. Fidale, A. Casella-Filho, P. Dourado, A. Chagas, Sadeq Ali-Hasan-Al-Saegh, P. E. O. Reis, R. Pinto, Gustavo B. F. Oliveira, Álvaro Avezum Mansueto Neto, A. Durães, R. Silva, A. J. Grande, C. Denardi, Renato D. Lopes, N. Nerlekar, S. Alizadeh, A. Hernandez, M. I. Rosa, G. Tse, Tong Liu, Roberto Furlanetto Júnior, C. L. Lourenço, G. Biondi‐Zoccai
{"title":"Effect of exercise on epicardial fat in adults: a protocol for systematic review and meta-analyses","authors":"L. Roever, E. S. Resende, A. Diniz, N. Penha-Silva, J. L. O’Connell, Fernanda Rodrigues Souza, Poliana Rodrigues Alves Duarte, L. Lopes, P. F. Gomes, H. R. Zanetti, Anaisa Silva Roerver-Borges, F. Veloso, T. Fidale, A. Casella-Filho, P. Dourado, A. Chagas, Sadeq Ali-Hasan-Al-Saegh, P. E. O. Reis, R. Pinto, Gustavo B. F. Oliveira, Álvaro Avezum Mansueto Neto, A. Durães, R. Silva, A. J. Grande, C. Denardi, Renato D. Lopes, N. Nerlekar, S. Alizadeh, A. Hernandez, M. I. Rosa, G. Tse, Tong Liu, Roberto Furlanetto Júnior, C. L. Lourenço, G. Biondi‐Zoccai","doi":"10.15761/JIC.1000272","DOIUrl":null,"url":null,"abstract":"Introduction: Epicardial adipose tissue (EAT) is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. This study aims to fill this gap of research by conducting a systematic review and meta-analysis to compare differences types of exercise to reduce EAT. Methods and analysis: We will search the PubMed, EMBASE, Cochrane Library, Web of Science, Embase, google scholar, clinical trials registry (ClinicalTrials. gov) for unpublished or undergoing research listed in registry platforms. Randomized controlled trials (RCTs) on the drug therapy of EAT with outcome measures including diagnostic criteria of EAT will be included. The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool. Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed. The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool. Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed. Ethics and dissemination: Ethics approval was not required for this study because it was based on published studies and this study will be submitted in a scientific peer-reviewed journal. Trial registration number: PROSPERO (CRD42018096581). *Correspondence to: Leonardo Roever, Department of Clinical Research, Federal University of Uberlândia, Heart Institute (InCor), Master Institute of Education President Antonio Carlos, IMEPAC, Araguari, Brazil, E-mail: leonardoroever@hotmail.com","PeriodicalId":91545,"journal":{"name":"Journal of integrative cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of integrative cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/JIC.1000272","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Epicardial adipose tissue (EAT) is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. This study aims to fill this gap of research by conducting a systematic review and meta-analysis to compare differences types of exercise to reduce EAT. Methods and analysis: We will search the PubMed, EMBASE, Cochrane Library, Web of Science, Embase, google scholar, clinical trials registry (ClinicalTrials. gov) for unpublished or undergoing research listed in registry platforms. Randomized controlled trials (RCTs) on the drug therapy of EAT with outcome measures including diagnostic criteria of EAT will be included. The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool. Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed. The quality of included RTCs will be evaluated according to the Cochrane Collaboration's risk of bias tool. Sensitivity analysis on the sample size of RCTs, meta-regression analysis on the follow-up periods, dosages and baselines of outcome measure, contradiction analysis between pairwise and network meta-analyses, and publication bias analysis, will be performed. Ethics and dissemination: Ethics approval was not required for this study because it was based on published studies and this study will be submitted in a scientific peer-reviewed journal. Trial registration number: PROSPERO (CRD42018096581). *Correspondence to: Leonardo Roever, Department of Clinical Research, Federal University of Uberlândia, Heart Institute (InCor), Master Institute of Education President Antonio Carlos, IMEPAC, Araguari, Brazil, E-mail: leonardoroever@hotmail.com
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