Self-Assembly Polymeric Nano Micelles for the Futuristic Treatment of Skin Cancer and Phototoxicity: Therapeutic and Clinical Advancement.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2022-01-01 DOI:10.1615/critrevtherdrugcarriersyst.2021035589

N. Mehan, Manish Kumar, S. Bhatt, R. Shankar, B. Kumari, R. Pahwa, Deepak Kaushik

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引用次数: 7

Abstract

In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized drug delivery system. The polymeric micelles are designed from synthetic block co-polymers and graft copolymers. In the mixed micelles, the bilayer lipid membrane and surfactants are used. Both micelles are in nano-sized and used to enhance the drug delivery to treat different diseases. In this review, we will discuss some examples from the literature included demonstrating the polymeric micelles used as drug-carriers in skin cancer treatment by using different drugs. We also summarized mixed micelles, polymeric micelles in skin drug delivery, various polymers, and techniques of polymeric micelles. These micelles may improve delivery of drug in the skin's targeted sites in specific and dermatological diseases like skin cancer, acne, and fungal infection. In the comparison of surfactant micelles, the polymeric micelles are more stable. Polymeric micelles act as a colloidal carrier for incorporating poorly water-soluble and amphiphilic drugs.

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自组装聚合物纳米胶束用于皮肤癌和光毒性的未来治疗:治疗和临床进展。

近年来，高分子胶束作为药物载体在纳米给药系统中发挥了重要作用。聚合物胶束是由合成的嵌段共聚物和接枝共聚物设计而成的。在混合胶束中，使用双层脂质膜和表面活性剂。这两种胶束都是纳米级的，用于增强药物传递，以治疗不同的疾病。在这篇综述中，我们将讨论一些文献中的例子，包括通过不同的药物来证明聚合物胶束作为药物载体在皮肤癌治疗中的应用。综述了混合胶束、聚合物胶束在皮肤给药中的应用、各种聚合物和聚合物胶束技术。这些胶束可以改善特定皮肤疾病(如皮肤癌、痤疮和真菌感染)的靶向部位的药物递送。与表面活性剂胶束相比，聚合物胶束更稳定。聚合物胶束作为一种胶体载体，将水溶性差的两亲性药物结合在一起。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.

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