A Profound Relationship between Circadian Rhythm Dysfunction and Cancer Progression: An Approach to Exploration.

Q4 Biochemistry, Genetics and Molecular Biology
S. Samanta
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引用次数: 1

Abstract

Circadian (~ 24-hour) rhythm has been observed in all living organisms. In humans, the circadian system governs different physiological functions such as metabolism, sleep-wake cycle, body temperature, hormone secretion, and cellular proliferation. The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the principal circadian pacemaker. The SCN receives input signals primarily from the retinohypothalamic tract (RHT), sends output signals to different parts of the hypothalamus, pineal gland, and the peripheral clocks through the neural or humoral network. The functions of the circadian clock are mediated by the rhythmic expression of the core clock genes through a complex feedback loop. Disruption of clock functions influences the development of several pathologic conditions, including cancer, shift work, chronic or acute jet lag, and light-at-night affect the circadian activity, leading to development of several physiological disorders, more specifically cancer. Circadian dysfunction alters the expression of core clock genes that promote the deregulation of the cell cycle, increase cell proliferation and survival, decrease apoptotic activity, alter metabolic functions, increase metastatic property, collectively induces cancer progression.
昼夜节律障碍与癌症进展之间的深刻关系:一种探索方法。
所有生物都有昼夜节律(~ 24小时)。在人类中,昼夜节律系统控制着不同的生理功能,如新陈代谢、睡眠-觉醒周期、体温、激素分泌和细胞增殖。下丘脑前部的视交叉上核(SCN)是主要的昼夜节律起搏器。SCN主要接收来自视网膜下丘脑束(retinohypothalamic tract, RHT)的输入信号,并通过神经或体液网络将输出信号发送到下丘脑、松果体和外周时钟的不同部位。生物钟的功能是通过一个复杂的反馈回路,由核心生物钟基因的节律性表达介导的。生物钟功能的破坏会影响多种病理状况的发展,包括癌症、轮班工作、慢性或急性时差反应,而夜间的光线会影响昼夜节律活动,导致几种生理障碍的发展,更具体地说,是癌症。昼夜节律障碍改变核心时钟基因的表达,这些基因促进细胞周期的失调,增加细胞增殖和存活,降低凋亡活性,改变代谢功能,增加转移性,共同诱导癌症进展。
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来源期刊
Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.
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