{"title":"Insights into Oncogenesis from Circadian Timing in Cancer Stem Cells.","authors":"M. Geusz, Astha Malik, Arpan De","doi":"10.1615/critrevoncog.2021041960","DOIUrl":null,"url":null,"abstract":"Cancer and circadian rhythms are linked in several ways, through immunomodulatory, neuroendocrine, and metabolic pathways. The circadian timing system consists of interacting circadian clocks in organs throughout the body that contain cells endowed with self-sustaining molecular circadian oscillations. Circadian rhythms are spontaneously generated by specific transcription and translation feedback cycles. Cancer cells emerging from these rhythmic tissues are subjected to daily physiological rhythms imposed by the circadian system, and some transformed cells have their own intrinsic circadian clocks. The role of these circadian clock cells in cancer prevention and oncogenesis remains to be fully explored. Nevertheless, evidence suggests that new cancers are fostered by degradation of the circadian system's rhythmic properties. In contrast, circadian clocks within cancer cells might aid in their survival if they provide benefits such as an ability to synchronize with daily nutrient availability or circadian rhythms in immune cell activity. Here, we address new evidence challenging the simplicity of carcinogenesis models that depend solely on the importance of minimized cancer risk provided by well-aligned and robust circadian clocks in the body. The biology of cancer stem cells and the benefits they may receive from their own rhythmic and non-rhythmic expressions of core circadian clock genes are examined with a focus on gliomas and liver cancer stem cells, along with possibilities for timed medical interventions.","PeriodicalId":35617,"journal":{"name":"Critical Reviews in Oncogenesis","volume":"26 4 1","pages":"1-17"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Oncogenesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/critrevoncog.2021041960","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 2
Abstract
Cancer and circadian rhythms are linked in several ways, through immunomodulatory, neuroendocrine, and metabolic pathways. The circadian timing system consists of interacting circadian clocks in organs throughout the body that contain cells endowed with self-sustaining molecular circadian oscillations. Circadian rhythms are spontaneously generated by specific transcription and translation feedback cycles. Cancer cells emerging from these rhythmic tissues are subjected to daily physiological rhythms imposed by the circadian system, and some transformed cells have their own intrinsic circadian clocks. The role of these circadian clock cells in cancer prevention and oncogenesis remains to be fully explored. Nevertheless, evidence suggests that new cancers are fostered by degradation of the circadian system's rhythmic properties. In contrast, circadian clocks within cancer cells might aid in their survival if they provide benefits such as an ability to synchronize with daily nutrient availability or circadian rhythms in immune cell activity. Here, we address new evidence challenging the simplicity of carcinogenesis models that depend solely on the importance of minimized cancer risk provided by well-aligned and robust circadian clocks in the body. The biology of cancer stem cells and the benefits they may receive from their own rhythmic and non-rhythmic expressions of core circadian clock genes are examined with a focus on gliomas and liver cancer stem cells, along with possibilities for timed medical interventions.
期刊介绍:
The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.