Insights into Oncogenesis from Circadian Timing in Cancer Stem Cells.

Q4 Biochemistry, Genetics and Molecular Biology
M. Geusz, Astha Malik, Arpan De
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引用次数: 2

Abstract

Cancer and circadian rhythms are linked in several ways, through immunomodulatory, neuroendocrine, and metabolic pathways. The circadian timing system consists of interacting circadian clocks in organs throughout the body that contain cells endowed with self-sustaining molecular circadian oscillations. Circadian rhythms are spontaneously generated by specific transcription and translation feedback cycles. Cancer cells emerging from these rhythmic tissues are subjected to daily physiological rhythms imposed by the circadian system, and some transformed cells have their own intrinsic circadian clocks. The role of these circadian clock cells in cancer prevention and oncogenesis remains to be fully explored. Nevertheless, evidence suggests that new cancers are fostered by degradation of the circadian system's rhythmic properties. In contrast, circadian clocks within cancer cells might aid in their survival if they provide benefits such as an ability to synchronize with daily nutrient availability or circadian rhythms in immune cell activity. Here, we address new evidence challenging the simplicity of carcinogenesis models that depend solely on the importance of minimized cancer risk provided by well-aligned and robust circadian clocks in the body. The biology of cancer stem cells and the benefits they may receive from their own rhythmic and non-rhythmic expressions of core circadian clock genes are examined with a focus on gliomas and liver cancer stem cells, along with possibilities for timed medical interventions.
从肿瘤干细胞的昼夜节律时序了解肿瘤发生。
癌症和昼夜节律通过免疫调节、神经内分泌和代谢途径以多种方式联系在一起。昼夜节律计时系统由身体各个器官中的相互作用的昼夜节律时钟组成,这些器官中含有被赋予自我维持的分子昼夜节律振荡的细胞。昼夜节律是由特定的转录和翻译反馈周期自发产生的。从这些节律性组织中产生的癌细胞受到昼夜节律系统施加的日常生理节律的影响,一些转化的细胞有自己内在的昼夜节律钟。这些生物钟细胞在癌症预防和肿瘤发生中的作用仍有待充分探索。然而,有证据表明,新的癌症是由昼夜节律系统的节律特性的退化引起的。相比之下,如果癌细胞内的生物钟能够提供与免疫细胞活动中的每日营养可用性或昼夜节律同步的能力,那么它们可能有助于癌细胞的生存。在这里,我们提出了新的证据,挑战了癌症发生模型的简单性,这些模型仅仅依赖于由身体中排列良好和强大的生物钟提供的最小化癌症风险的重要性。癌症干细胞的生物学特性及其可能从其核心生物钟基因的节律性和非节律性表达中获得的益处,重点是胶质瘤和肝癌干细胞,以及定时医疗干预的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
1.70
自引率
0.00%
发文量
17
期刊介绍: The journal is dedicated to extensive reviews, minireviews, and special theme issues on topics of current interest in basic and patient-oriented cancer research. The study of systems biology of cancer with its potential for molecular level diagnostics and treatment implies competence across the sciences and an increasing necessity for cancer researchers to understand both the technology and medicine. The journal allows readers to adapt a better understanding of various fields of molecular oncology. We welcome articles on basic biological mechanisms relevant to cancer such as DNA repair, cell cycle, apoptosis, angiogenesis, tumor immunology, etc.
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