Beneficial Effects of Urapidil Against Renal Ischemia Reperfusion-Related Renal Injury

Abstract

Objective: The potential protective effects of urapidil (Ura) against renal injury composed by ischemia reperfusion (I/R) were examined. Methods: The experimental animals were assigned to sham, I/R, I/R + Ura 0.5 mg/kg, and I/R + Ura 5 mg/kg groups. Total antioxidant status (TAS), superoxide dismutase (SOD), total oxidant status (TOS), myeloperoxidase (MPO), oxidative stress index (OSI), and malondialdehyde (MDA) parameters were determined. Results: MDA, TOS, MPO, and OSI values elevated, but TAS and SOD levels declined in the I/R group. Ura treatment reversed these parameters. In addition, immunopositivity of interleukin-1 beta and tumor necrosis factor-alpha were severe in the I/R group but declined due to Ura administration. Conclusion: The results of the study showed that Ura is highly effective against renal damage induced by I/R. ABSTRACT