Monodispersed strontium containing bioactive glass nanoparticles and MC3T3-E1 cellular response

Q1 Materials Science

Biomedical Glasses Pub Date : 2016-01-05 DOI:10.1515/bglass-2016-0009

Parichart Naruphontjirakul, Sarah L. Greasley, Shu Chen, A. Porter, Julian R. Jones

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引用次数: 28

Abstract

Abstract Non-porous monodispersed strontium containing bioactive glass (Si2O-CaO-SrO) nanoparticles (Sr- BGNPs), were synthesised using a modified Stöber process. Silica nanoparticles (Si-NPs) with diameters 90 ± 10 nm were produced through hydrolysis and polycondensation reactions of the silicon alkoxide precursor, tetraethyl orthosilicate (TEOS), prior to the incorporation of cations; calcium (Ca) and strontium (Sr), into the silica networks through heat treatment (calcination). Sr was substituted for Ca on a mole basis from non- (0SrBGNPs) to fullsubstitution (100SrBGNPs) in order to increase the amount of network modifiers in the Si-NPs. The different ratios of Si: Ca; 1:1.3 and 1:8.0, presented various elemental compositions (i.e. 77–92 mol% of SiO2). The effect of Si: Ca/Sr ratio on particle size, morphology and dispersitywas evaluated, as well as the in vitro cell viability effect of Sr- BGNPs and their dissolution products on pre-osteoblast cell line, MC3T3-E1. Sr incorporation did not affect particle size or dispersity. For 1:1.3 ratio, SrBGNPs caused no toxic effects on the cells and dissolution products of 75- and 100- SrBGNPs showed great potential to promote MC3T3-E1 activity.

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单分散含锶生物活性玻璃纳米颗粒与MC3T3-E1细胞反应

摘要:采用改进的Stöber工艺合成了无孔单分散含生物活性玻璃(si20 - cao - sro)纳米粒子(Sr- BGNPs)。在阳离子掺入之前，通过硅烷氧化物前驱体正硅酸四乙酯(TEOS)的水解缩聚反应制备了直径为90±10 nm的二氧化硅纳米颗粒(Si-NPs);钙(Ca)和锶(Sr)，通过热处理(煅烧)进入二氧化硅网络。为了增加Si-NPs中网络改性剂的数量，以摩尔为单位将Ca从非(0SrBGNPs)取代为全取代(100SrBGNPs)。不同比例的Si: Ca;1:13 .3和1:8.0，呈现出不同的元素组成(即77 ~ 92 mol%的SiO2)。研究了Si: Ca/Sr配比对成骨前细胞株MC3T3-E1的颗粒大小、形态和分散性的影响，以及Sr- BGNPs及其溶出产物对成骨前细胞株MC3T3-E1体外细胞活力的影响。锶掺入不影响颗粒的大小和分散性。在1:1.3的比例下，SrBGNPs对细胞没有毒性作用，75-和100- SrBGNPs的溶出产物对MC3T3-E1活性有很大的促进作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.