Structuring of bioactive glass surfaces at the micrometer scale by direct casting intended to influence cell response

Q1 Materials Science
Barbara Pföss, M. Höner, Monika Wirth, A. Bührig-Polaczek, H. Fischer, R. Conradt
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引用次数: 1

Abstract

Abstract Defect-free bioactive glass surfaces with a grooved microstructure at the low micrometer scale were achieved by a mold casting process. The process was applied to the well-known glass compositions 45S5 and 13–93. Such microstructured surfaces may exhibit especially favorable conditions for bone cell orientation and growth. The aim of the study was to assess the parameter range for a successful casting process and thus to produce samples suitable to investigate the interaction between structured surfaces and relevant cells. Viscous flow in its temperature dependence and thermal analysis were analyzed to identify a suitable process window and to design a manageable time-temperature process scheme. Counteracting effects such as formation of chill ripples, mold sticking and build-up of permanent thermal stress in the glass had to be overcome. A platinum gold alloy was chosen as mold material with the mold surface bearing the mother shape of the microstructure to be imprinted on the glass surface. First experiments studying the behavior of osteoblast-like cells, seeded on these microstructured glass surfaces revealed excellent viability and an orientation of the cells along the microgrooves. The presented results show that direct casting is a suitable process to produce defined microstructures on bioactive glass surfaces.
通过直接铸造在微米尺度上构建生物活性玻璃表面,旨在影响细胞反应
摘要采用模具铸造工艺,在低微米尺度上获得了具有沟槽微结构的无缺陷生物活性玻璃表面。该工艺应用于著名的玻璃组合物45S5和13-93。这种微结构表面可能对骨细胞的定向和生长表现出特别有利的条件。该研究的目的是评估成功铸造工艺的参数范围,从而产生适合研究结构表面和相关细胞之间相互作用的样品。对粘性流动的温度依赖性和热分析进行了分析,确定了合适的过程窗口,设计了可管理的时间-温度过程方案。必须克服诸如冷波纹的形成、模具粘着和玻璃中永久热应力的积累等抵消效应。选用铂金合金作为模具材料,模具表面承载着待压印在玻璃表面的微观结构的母形。第一次实验研究了在这些微结构的玻璃表面上播种的成骨细胞样细胞的行为,结果显示了良好的活力和细胞沿着微槽的方向。结果表明,直接铸造是在生物活性玻璃表面产生明确微观结构的合适工艺。
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来源期刊
Biomedical Glasses
Biomedical Glasses Materials Science-Surfaces, Coatings and Films
自引率
0.00%
发文量
0
审稿时长
17 weeks
期刊介绍: Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.
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