Bioaccessibility and health risk of neonicotinoids in apple and pear samples as affected by in vitro digestion

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Quality Assurance and Safety of Crops & Foods Pub Date : 2021-01-01 DOI:10.15586/qas.v13i3.946

Jia-Yu Wang, Dong Wei, Yanwu Deng, Wenxiao Feng, Qun Gao, Yan-hong Shi, Jinjing Xiao

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引用次数: 15

Abstract

Previous studies have only focused on the bioaccessibility of single pesticide/metal without considering the potential impact of post-uptake interactions on bioaccessibility of pesticides/metals in the human digestive system. Hence, the influences of chromium (Cr) speciation on neonicotinoids bioaccessibility were investigated and the potential health risk based on the oral bioaccessibility was evaluated. Bioaccessibility of four neonicotinoids in apple and pear was measured using three common in vitro methods (SBRC, PBET, and IVG). Bioaccessibility of neonicotinoids in apple and pear varied between in vitro methods, which may reflect the difference of determination parameters (i.e., pH values, incubation time, and constituents). The neonicotinoids bioaccessibility was remarkably reduced by 17.21–81.21% and 11.61–73.70% with the addition of Cr(III) and Cr(VI), respectively. Risk assessment based on the hazard quotient (HQ) with bioaccessibility revealed that exposure to pesticide residues in the tested fruits were all below levels that might pose a health risk. These findings are of theoretical value for the safety evaluation of pesticide residues on food.

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苹果和梨样品中新烟碱的生物可及性及健康风险研究

以往的研究只关注单一农药/金属的生物可及性，没有考虑摄取后相互作用对农药/金属在人体消化系统中生物可及性的潜在影响。因此，研究了铬形态对新烟碱类药物生物可及性的影响，并基于口服生物可及性评价其潜在健康风险。采用三种常用的体外方法(SBRC、PBET和IVG)测定了苹果和梨中4种新烟碱类化合物的生物可及性。苹果和梨中新烟碱的生物可及性在不同的离体方法中存在差异，这可能反映了测定参数(pH值、培养时间和成分)的差异。添加Cr(III)和Cr(VI)后，新烟碱类生物可及性分别降低17.21 ~ 81.21%和11.61 ~ 73.70%。基于危害商(HQ)和生物可及性的风险评估显示，受测水果中农药残留的暴露均低于可能构成健康风险的水平。研究结果对食品中农药残留的安全性评价具有一定的理论价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.