Syndecan-1 levels predict septic shock in critically ill patients with COVID-19.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-04 DOI:10.1093/trstmh/trad077

Nilcyeli Linhares Aragão, Marza de Sousa Zaranza, Gdayllon Cavalcante Meneses, Ana Paula Pires Lázaro, Álvaro Rolim Guimarães, Alice Maria Costa Martins, Natalia Linhares Ponte Aragão, Andrea Mazza Beliero, Geraldo Bezerra da Silva Júnior, Sandra Mara Brasileiro Mota, Polianna Lemos Moura Moreira Albuquerque, Elizabeth De Francesco Daher, Veralice Meireles Sales De Bruin, Pedro Felipe Carvalhedo de Bruin

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引用次数: 0

Abstract

Background: The clinical picture of coronavirus disease 2019 (COVID-19)-associated sepsis is similar to that of sepsis of other aetiologies. The present study aims to analyse the role of syndecan-1 (SDC-1) as a potential predictor of septic shock in critically ill patients with COVID-19.

Methods: This is a prospective study of 86 critically ill patients due to COVID-19 infection. Patients were followed until day 28 of hospitalization. Vascular biomarkers, such as vascular cell adhesion protein-1, SDC-1, angiopoietin-1 and angiopoietin-2, were quantified upon admission and associated with the need for vasopressors in the first 7 d of hospitalization.

Results: A total of 86 patients with COVID-19 (mean age 60±16 y; 51 men [59%]) were evaluated. Thirty-six (42%) patients died during hospitalization and 50 (58%) survived. The group receiving vasopressors had higher levels of D-dimer (2.46 ng/ml [interquartile range {IQR} 0.6-6.1] vs 1.01 ng/ml [IQR 0.62-2.6], p=0.019) and lactate dehydrogenase (929±382 U/l vs 766±312 U/l, p=0.048). The frequency of deaths during hospitalization was higher in the group that received vasoactive amines in the first 24 h in the intensive care unit (70% vs 30%, p=0.002). SDC-1 levels were independently associated with the need for vasoactive amines, and admission values >269 ng/ml (95% CI 0.524 to 0.758, p=0.024) were able to predict the need for vasopressors during the 7 d following admission.

Conclusions: Syndecan-1 levels predict septic shock in critically ill patients with COVID-19.

查看原文本刊更多论文

Syndecan-1水平预测新冠肺炎危重患者感染性休克。

背景：2019冠状病毒病（新冠肺炎）相关脓毒症的临床表现与其他病因的脓毒症相似。本研究旨在分析综合征-1（SDC-1）作为COVID-19危重患者感染性休克的潜在预测因子的作用。患者被随访至住院第28天。血管生物标志物，如血管细胞粘附蛋白-1、SDC-1、血管生成素-1和血管生成素-2，在入院时进行定量，并与住院前7天对血管升压药的需求相关。结果：共评估了86名新冠肺炎患者（平均年龄60±16岁；51名男性[59%]）。36名（42%）患者在住院期间死亡，50名（58%）患者存活。接受血管升压药的组的D-二聚体水平较高（2.46 ng/ml[四分位间距{IQR}0.6-6.1]vs 1.01 ng/ml[IQR0.62-2.6]，p=0.019）和乳酸脱氢酶水平较高（929±382 U/l vs 766±312 U/l，p=0.048）。在重症监护室的前24小时接受血管活性胺的组住院期间的死亡频率较高（70%vs 30%，p=0.002）。SDC-1水平与对血管活性胺的需求独立相关，入院值>269 ng/ml（95%CI 0.524-0.758，p=0.024）能够预测入院后7天对血管升压药的需求。结论：Syndecan-1水平可预测新冠肺炎危重患者的感染性休克。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.