Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis.

IF 1.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ebru Yilmaz, Sena Ünver
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引用次数: 0

Abstract

The maintenance of various physiological cellular processes requires mineral magnesium (Mg). The purpose of the study was to determine a possible association between Mg level and vitamin D levels, bone mineral density (BMD), chronic diseases, and radiographic stage in individuals with knee osteoarthritis (OA). The study included 98 individuals (62 female and 36 male) who had been diagnosed with at least grade 1 knee OA. Age, sex, smoking, body mass index (BMI), family history of osteoporosis, menopausal status, duration of menopause, the presence of chronic diseases (hypertension, diabetes mellitus, hyperlipidaemia, coronary artery disease, hypothyroidism) and radiological stage of knee OA were gathered from all patients. Also, serum calcium, Mg, alkaline phosphatase, parathyroid hormone (PTH) and 25(OH)-vitamin D levels were recorded. Additionally, dual-energy X-ray absorptiometry (DEXA) was used to measure the BMD of the lumbar vertebrae (L1-L4) and femoral neck as well as anteroposterior radiography of the knee in all patients. T scores ≤-2.5 were accepted as evidence of osteoporosis. The mean age of the study population was 59.15 ± 10.58 years. The level of Mg significantly correlated with age, smoking, presence of chronic disease, duration of menopause, the level of vitamin D and PTH, and femoral neck T score (p<0.05). This study provides data supporting the relationship between magnesium levels and PTH and vitamin D levels, bone mineral density, and chronic disease. Future research is needed to examine the potential link between knee osteoarthritis and magnesium status.

膝骨关节炎患者镁水平与维生素D、骨密度和慢性疾病关系的研究。
维持各种生理细胞过程需要矿物质镁(Mg)。本研究的目的是确定膝骨关节炎(OA)患者的镁水平和维生素D水平、骨密度(BMD)、慢性疾病和放射学分期之间的可能联系。该研究包括98名被诊断为至少1级膝关节骨性关节炎的患者(62名女性和36名男性)。收集所有患者的年龄、性别、吸烟、体重指数(BMI)、骨质疏松家族史、更年期状况、更年期持续时间、是否患有慢性疾病(高血压、糖尿病、高脂血症、冠状动脉疾病、甲状腺功能减退)和膝关节骨性关节炎的放射学分期。此外,还记录了血清钙、镁、碱性磷酸酶、甲状旁腺激素(PTH)和25(OH)-维生素D水平。此外,使用双能X射线吸收仪(DEXA)测量所有患者的腰椎(L1-L4)和股骨颈的BMD以及膝关节的前后位X线片。T评分≤-2.5被认为是骨质疏松症的证据。研究人群的平均年龄为59.15±10.58岁。镁水平与年龄、吸烟、是否患有慢性病、绝经时间、维生素D和甲状旁腺激素水平以及股骨颈T评分显著相关(p
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来源期刊
Magnesium research
Magnesium research 医学-内分泌学与代谢
CiteScore
3.50
自引率
9.40%
发文量
6
审稿时长
>12 weeks
期刊介绍: Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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