Trend of Antibiotic Susceptibility of Haemophilus influenzae Isolated from Children, 2014–2019

Q3 Medicine

Pediatric Infection and Vaccine Pub Date : 2020-01-01 DOI:10.14776/piv.2020.27.e25

Euntaek Lee, Sera Park, Mina Kim, Jina Lee

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Abstract

147 ABSTRACT Purpose: We investigated the trend of antibiotic susceptibility of Haemophilus influenzae over 5 consecutive years. Methods: We analyzed the antibiotic susceptibility of H. influenzae isolated from children aged <18 years, who were admitted to the Asan Medical Center Children's Hospital from March 2014 to April 2019. Antibiotic susceptibility of H. influenzae was determined by the disk diffusion test according to the European Committee on Antimicrobial Susceptibility Testing guidelines. Results: Excluding duplicates, 69 isolates were obtained over the past 5 years. The median age of the patients was 5 years (range, 2.8–8.6 years). The antibiotic susceptibility patterns were as follows: ampicillin (AMP)-susceptible/amoxicillin-clavulanate (AMC)-susceptible (AS/ACS; n=15 [21.7%]), AMP-resistant/AMC-susceptible (AR/ACS; n=21 [30.4%]), and AMP-resistant/ AMC-resistant (AR/ACR; n=33 [47.8%]). The prevalence of isolates with AR/ACR phenotype tended to increase from 42.1% in 2014–2015 to 54.5% in 2018–2019 ( P =0.342). Compared to 2014–2015, the resistance rates to cefuroxime and ceftriaxone in 2018–2019 increased from 31.6% to 77.3% and from 0.0% to 59.1%, respectively ( P =0.003 and P <0.001, respectively). Conclusions: Over the last 5 years, H. influenzae isolates with AR/ACR phenotype and ceftriaxone resistance were frequently observed at our institute. The incidence of resistance to cefuroxime and ceftriaxone has increased significantly.

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2014-2019年儿童流感嗜血杆菌药敏趋势分析

摘要目的:研究流感嗜血杆菌连续5年的抗生素敏感性变化趋势。方法:对2014年3月至2019年4月峨山医疗中心儿童医院收治的18岁以下儿童流感嗜血杆菌进行抗生素敏感性分析。根据欧洲抗菌素敏感性试验委员会的指导方针，采用圆盘扩散试验确定流感嗜血杆菌的抗生素敏感性。结果:排除重复，共分离69株。患者的中位年龄为5岁(范围2.8-8.6岁)。药敏型为氨苄西林(AMP)敏感/阿莫西林-克拉维酸(AMC)敏感(as /ACS);n=15[21.7%])，耐药/易感(AR/ACS;n=21 [30.4%])， amp耐药/ amc耐药(AR/ACR;n = 33[47.8%])。AR/ACR表型分离株的流行率从2014-2015年的42.1%上升至2018-2019年的54.5% (P =0.342)。与2014-2015年相比，2018-2019年对头孢呋辛和头孢曲松的耐药率分别从31.6%上升至77.3%，从0.0%上升至59.1% (P =0.003, P <0.001)。结论:在过去的5年中，我们研究所经常观察到AR/ACR表型和头孢曲松耐药的流感嗜血杆菌分离株。头孢呋辛和头孢曲松耐药发生率明显增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.