Incidence and Characteristics of Clostridioides difficile Infection in Children

Q3 Medicine

Pediatric Infection and Vaccine Pub Date : 2020-01-01 DOI:10.14776/piv.2020.27.e24

H. Jeong, Ji‐Man Kang, Jong Gyun Ahn

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引用次数: 1

Abstract

Purpose: We evaluated the incidence and characteristics of Clostridioides difficile infection (CDI) in Korean children. Methods: Medical records of patients aged 2–18 years and diagnosed with CDI at a tertiary hospital between 2009 and 2018 were analyzed. The patients were classified into three CDI groups: community-acquired (CA), community onset-health care facility-associated (COHCFA), and healthcare facility onset (HO). Results: The incidence of CDI increased from 1.00 to 10.01 cases per 10,000 admissions from 2009 to 2018 (P<0.001). As compared to the CA group, the HO group had a higher frequency of operation and malignancy as predisposing factors (40.4% vs. 0.0%, P=0.001; and 27.7% vs. 0.0%, P=0.027, respectively), frequency and number of previous antibiotic use (97.9% vs. 31.3%, P<0.001; and 2 vs. 0, P<0.001, respectively), and median postdiagnosis hospital stay (13 vs. 5 days, P=0.008). The CO-HCFA group had a lower median age and higher frequency of malignancy than the CA group (5 vs. 13 years, P=0.012; and 30.8% vs. 0.0%, P=0.030, respectively). As compared to the HO group, the CA group had a higher frequency of abdominal pain and hematochezia (56.3% vs. 10.6%, P=0.001; and 50.0% vs. 10.6%, P=0.002, respectively), inflammatory bowel disease (68.8% vs. 2.1%, P=0.001), and intravenous metronidazole treatment (37.5% vs. 2.1%, P=0.001). Conclusions: With the increasing incidence of pediatric CDI, awareness regarding its epidemiology and clinical characteristics is important to manage nosocomial infections.

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儿童艰难梭菌感染的发生率及特点

目的:评估韩国儿童艰难梭菌感染(CDI)的发生率和特点。方法:对某三级医院2009 - 2018年2-18岁CDI患者的病历进行分析。患者被分为三个CDI组:社区获得性(CA)、社区发病-卫生保健机构相关(COHCFA)和卫生保健机构发病(HO)。结果:2009年至2018年，CDI发生率从1.00 /万上升至10.01 /万(P<0.001)。与CA组相比，HO组的手术频率和恶性肿瘤为高危因素(40.4%比0.0%，P=0.001;和27.7%比0.0%，P=0.027)，既往抗生素使用频率和次数(97.9%比31.3%，P<0.001;和2对0,P<0.001)，以及诊断后住院时间中位数(13对5天，P=0.008)。CO-HCFA组的中位年龄低于CA组，恶性肿瘤发生率高于CA组(5岁vs. 13岁，P=0.012;30.8% vs. 0.0%， P=0.030)。与HO组相比，CA组出现腹痛和便血的频率更高(56.3%比10.6%，P=0.001;和50.0%对10.6%，P=0.002)，炎症性肠病(68.8%对2.1%，P=0.001)，静脉注射甲硝唑治疗(37.5%对2.1%，P=0.001)。结论:随着小儿CDI发病率的上升，了解其流行病学和临床特点对医院感染的管理具有重要意义。

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来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.