Analysis of the Change in Seropositive Rate of Epstein-Barr Virus in Koreans: A Single-Center Study

Q3 Medicine

Pediatric Infection and Vaccine Pub Date : 2020-01-01 DOI:10.14776/piv.2020.27.e18

Su Kyung Kim, Joon-sik Choi, Dongsub Kim, C. Kang, D. Chung, K. Peck, E. Kang, Yae-Jean Kim

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引用次数: 2

Abstract

Purpose: Epstein-Barr virus (EBV) infection is related to infectious mononucleosis or nasopharyngeal cancer, and its epidemiology may change according to the socioeconomic development of communities. This study aimed to evaluate the recent epidemiology of EBV seropositive rate in Korea. Methods: We retrospectively reviewed EBV serology test results obtained from a part of clinical care at Samsung Medical Center, Seoul, South Korea, from January 2000 to December 2017. Results: The EBV seropositive rate in 26,527 subjects during the study period was 81.0% (21,485/26,527): 44.4% (2,716/6,122) in subjects aged 0–9 years, 75.8% (2,077/2,739) in those aged 10–19 years, and 94.5% (16,692/17,666) in those aged ≥20 years. The EBV seropositive rate decreased from 89.4% (8,592/9,616) in 2000–2008 to 76.2% (12,893/16,911) in 2009– 2017 ( P <0.001). Especially, the EBV seropositive rate in subjects aged 0–19 years significantly decreased from 2000–2008 to 2009–2017 (0–9 years, 62.8% [1,172/1,866] in 2000–2008 and 36.3% [1,544/4,256] in 2009–2017; 10–19 years, 83.8% [745/858] in 2000–2008 and 70.8% (1,332/1,881) in 2009–2017) ( P <0.001). Conclusions: The EBV seropositive rate in children has decreased in the last 20 years. As the age of patients with primary EBV infection increased, there is a need for interest in clinical manifestation, such as infectious mononucleosis, in adolescents and young adults.

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韩国人eb病毒血清阳性率变化分析:一项单中心研究

目的:eb病毒(Epstein-Barr virus, EBV)感染与传染性单核细胞增多症或鼻咽癌有关，其流行病学可能随着社区社会经济发展而发生变化。本研究旨在评估韩国EBV血清学阳性率的最新流行病学。方法:回顾性分析2000年1月至2017年12月韩国首尔三星医疗中心部分临床护理的EBV血清学检测结果。结果:研究期间，26527例受试者EBV血清阳性率分别为81.0%(21485 / 26527)、44.4%(2716 / 6122)、75.8%(2077 / 2739)、94.5%(16692 / 17666)。EBV血清阳性率从2000-2008年的89.4%(8592 / 9616)下降到2009 - 2017年的76.2% (12893 / 16911)(P <0.001)。其中，0 ~ 19岁人群EBV血清阳性率较2009 ~ 2017年显著下降(0 ~ 9岁，2000 ~ 2008年为62.8%[1172 / 1866]，2009 ~ 2017年为36.3% [1544 / 4256];10-19岁，2000-2008年为83.8%[745/858]，2009-2017年为70.8% (1332 / 1881)(P <0.001)。结论:近20年来，儿童EBV血清阳性率呈下降趋势。随着原发性EBV感染患者年龄的增加，有必要关注青少年和年轻人的临床表现，如传染性单核细胞增多症。

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来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.