Group A Streptococcal Bacteremia in Pediatric Patients: A Single-Center Study

Q3 Medicine

Pediatric Infection and Vaccine Pub Date : 2020-01-01 DOI:10.14776/piv.2020.27.e15

Dongsub Kim

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引用次数: 0

Abstract

Purpose: Group A streptococcus (GAS) is a common pathogen in pediatric patients and often causes acute pharyngotonsillitis and skin and soft tissue infections. In addition, bacteremia with significant morbidity and mortality can also occur. This study was conducted to describe the clinical manifestations and treatment outcomes of pediatric GAS bacteremia patients in Korea. Methods: This was a single-center, retrospective study. From January 2000 to December 2016, pediatric patients aged ≤18 years with GAS bacteremia were studied. Clinical manifestations, underlying diseases, intensive care unit stay, and antibiotic susceptibility were evaluated. Results: During the study period, 19 patients had GAS bacteremia. Ten (53%) were male, and the median age was 7.4 years (range, 0.3–17.4 years). Fourteen (74%) had chronic underlying diseases. Five (26%) were immunocompromised (leukemia and chronic kidney disease). Eight (42%) had lymphatic or vascular malformations, of which seven had lesions with signs of inflammation. Three (16%) developed pneumonia, and two of them received ventilator care. The 30-day mortality rate was 6% (1/19), and the cause of death was bacteremic pneumonia. All GAS isolates were sensitive to penicillin. Fifteen (79%) were sensitive to both erythromycin and clindamycin. Conclusions: This study identified various clinical manifestations of GAS bacteremia. GAS should be considered as a potential pathogen that can cause bacteremia and result in a serious clinical course.

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儿童患者的A组链球菌菌血症:一项单中心研究

目的:A群链球菌(GAS)是儿科患者常见的病原体，常引起急性咽扁桃体炎和皮肤软组织感染。此外，还可能发生具有显著发病率和死亡率的菌血症。本研究旨在描述韩国儿童GAS菌血症患者的临床表现和治疗结果。方法:本研究为单中心回顾性研究。研究对象为2000年1月至2016年12月≤18岁的儿童GAS菌血症患者。评估临床表现、基础疾病、重症监护病房住院时间和抗生素敏感性。结果:研究期间，19例患者出现GAS菌血症。男性10例(53%)，中位年龄7.4岁(0.3-17.4岁)。14人(74%)患有慢性基础疾病。5例(26%)免疫功能低下(白血病和慢性肾脏疾病)。8例(42%)有淋巴或血管畸形，其中7例病变伴有炎症征象。3例(16%)发生肺炎，其中2例接受了呼吸机护理。30天死亡率为6%(1/19)，死亡原因为细菌性肺炎。所有GAS分离株均对青霉素敏感。15例(79%)对红霉素和克林霉素均敏感。结论:本研究确定了GAS菌血症的多种临床表现。气体应被视为一种潜在的病原体，可引起菌血症并导致严重的临床病程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.