Sex Differences in Gastroesophageal Reflux Disease (GERD)

Daniel Scheese, Mohamad Chehab, C. A. Puig
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引用次数: 0

Abstract

Gastroesophageal reflux disease (GERD) is the most commonly diagnosed digestive disorder in the United States. Higher rates of non-erosive reflux disease (NERD) are found in females while higher rates of erosive reflux disease (ERD) are found in males. Pre-menopausal females appear to be protected from esophageal mucosal damage, as they demonstrate lower rates of ERD, Barrett’s esophagus, and esophageal adenocarcinoma. A protective effect of estrogen on the esophageal mucosa is thought to contribute to this decreased prevalence. A better understanding of sex-related differences in GERD may help alleviate the reported differences in outcomes between sexes regarding medical and surgical management.
胃食管反流病(GERD)的性别差异
胃食管反流病(GERD)是美国最常见的消化系统疾病。非糜烂性反流病(NERD)在女性中发病率较高,而糜烂性反流病(ERD)在男性中发病率较高。绝经前女性似乎不受食管黏膜损伤的影响,因为她们患ERD、Barrett食管和食管腺癌的几率较低。雌激素对食管黏膜的保护作用被认为是导致患病率下降的原因。更好地了解反流胃食管反流的性别相关差异可能有助于减轻已报道的性别间在医疗和手术治疗方面的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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