Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Anna Delprato, Emily Xiao, Devika Manoj
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引用次数: 0

Abstract

Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. In this systematic review we examine the roles of the DCX, COMT and FMR1 genes in the context of hippocampal neurogenesis with respect to these disorders with the aim of identifying important hubs and signaling pathways that may bridge these conditions. Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social behavior may converge at Wnt signaling, neuron migration, and axon and dendrite morphogenesis. Data derived from genomic research has identified a multitude of genes that are linked to brain disorders and developmental differences. Information about where and how these genes function and cooperate is lagging behind. The approach used here may help to shed light on the biological underpinnings in which key genes interface and may prove useful for the testing of specific hypotheses.

DCX、COMT和FMR1在社会行为和认知障碍中的关联
DCX、COMT和FMR1的遗传变异与智力残疾和社会行为相关的神经发育障碍有关。在这篇系统综述中,我们研究了DCX、COMT和FMR1基因在海马神经发生中与这些疾病相关的作用,目的是确定可能连接这些疾病的重要枢纽和信号通路。综上所述,我们的研究结果表明,在智力残疾和社会行为中,连接DCX、COMT和FMR1的因素可能在Wnt信号传导、神经元迁移、轴突和树突形态发生方面汇聚。来自基因组研究的数据已经确定了许多与大脑疾病和发育差异有关的基因。关于这些基因在哪里以及如何起作用和合作的信息落后。这里使用的方法可能有助于阐明关键基因界面的生物学基础,并可能证明对特定假设的测试有用。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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