Drug Toxicity and Adverse Drug Reactions in Children - A Brief Historical Review

I. Choonara, M. Rieder
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引用次数: 51

Abstract

AbstractDrug toxicity in association with adverse drug reactions is common in hospitalisedchildren. The toxicity of medicines in children is different to that seen in adults.There are also differences between different age groups of paediatric patientswith neonates being generally at greater risk for experiencing a drug-associatedadverse event. The major examples of drug toxicity that have occurred inpaediatric patients are reviewed ranging from percutaneous toxicity over 100years ago to formulation errors and toxicity associated with normal,developmental alterations in drug metabolism . The need to learn from previouscases of drug toxicity to prevent future cases is paramount. Paed Perinatal Drug Ther 2002; 5: 12– 18 Key words: Drug toxicity – drug metabolism – children Introduction Adverse drug reactions ( ADRs ) are commonclinical problems in both paediatric and adultmedicine. Over 9% of hospitalised children haveadverse reactions to therapy and up to 4% of allhospital admissions are the consequence of ADRs
儿童的药物毒性和药物不良反应-简要的历史回顾
摘要药物毒性合并药物不良反应在住院儿童中很常见。药物对儿童的毒性与对成人的毒性不同。不同年龄组的儿科患者之间也存在差异,新生儿通常面临更大的药物相关不良事件风险。本文回顾了发生在儿科患者身上的药物毒性的主要例子,从100多年前的经皮毒性到配方错误和与药物代谢正常发育改变相关的毒性。从以前的药物毒性病例中学习以预防未来的病例是至关重要的。围产期用药指南2002;[05:12 - 18]关键词:药物毒性药物代谢儿童导论药物不良反应(adr)是儿科和成人医学中常见的临床问题。超过9%的住院儿童对治疗有不良反应,高达4%的住院儿童是adr的后果
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