Inflammation-Related Factors in Haemorrhoids

IF 1.6 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Phlebology Pub Date : 1994-01-01 DOI:10.1177/0268355594009001s10

B. Limasset, F. Michel, R. Rey, G. Guarrigues, A. D. Paulet

{"title":"Inflammation-Related Factors in Haemorrhoids","authors":"B. Limasset, F. Michel, R. Rey, G. Guarrigues, A. D. Paulet","doi":"10.1177/0268355594009001s10","DOIUrl":null,"url":null,"abstract":"Objective: To establish whether eicosanoid production characterizes the inflammatory processes of the haemorrhoidal plexus. Design: Open, single patient group study. Setting: Private practice. Patients: Fourteen patients selected for haemorrhoidectomy. Interventions: Specimens were obtained during either the acute (five patients, group I) or chronic (nine patients, group II) phase of the disease. We assayed the concentrations of prostaglandins E2 (PGE2) and F2α (PGF2α) and of leukotriene B4 (LTB4) in the vascular and mucosal tissues of the anterior and posterior haemorrhoidal plexus. Results: Very high levels of prostaglandins were recorded (up to 1445 <g/g fresh tissue of PGE2 in group I), which were consistently higher in group II than group I (p <0.05, Wilcoxon distribution free test) for 10 out of 18 parameters measured. Four to 20 times more PGE2 than PGF2α was produced. These two eicosanoids were strongly correlated (0.73–0.93 according to sample). LTB4 production was up to 20 times lower than that of PGE2 (6–10 ng/g, group II; 17–52 ng/g, group I). Conclusions: PGF2α and LTB4 seem to be valuable independent study parameters to be included in the design of protocols investigating the action of anti-inflammatory agents on haemorrhoids.","PeriodicalId":20139,"journal":{"name":"Phlebology","volume":"9 1","pages":"30 - 33"},"PeriodicalIF":1.6000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0268355594009001s10","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phlebology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/0268355594009001s10","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To establish whether eicosanoid production characterizes the inflammatory processes of the haemorrhoidal plexus. Design: Open, single patient group study. Setting: Private practice. Patients: Fourteen patients selected for haemorrhoidectomy. Interventions: Specimens were obtained during either the acute (five patients, group I) or chronic (nine patients, group II) phase of the disease. We assayed the concentrations of prostaglandins E2 (PGE2) and F2α (PGF2α) and of leukotriene B4 (LTB4) in the vascular and mucosal tissues of the anterior and posterior haemorrhoidal plexus. Results: Very high levels of prostaglandins were recorded (up to 1445

查看原文本刊更多论文

痔疮的炎症相关因素

目的:探讨类二十烷酸的产生是否为痔神经丛炎症过程的特征。设计:开放、单患者组研究。背景:私人执业。患者:选择14例患者行痔疮切除术。干预措施:在疾病的急性期(5例患者，第一组)或慢性期(9例患者，第二组)获得标本。我们检测了前列腺素E2 (PGE2)、F2α (PGF2α)和白三烯B4 (LTB4)在前后痔丛血管和粘膜组织中的浓度。结果:在测量的18个参数中，有10个参数II组的前列腺素水平持续高于I组(p <0.05，无Wilcoxon分布检验)，I组的前列腺素水平非常高(I组高达1445

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Phlebology 医学-外周血管病

CiteScore

3.30

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The leading scientific journal devoted entirely to venous disease, Phlebology is the official journal of several international societies devoted to the subject. It publishes the results of high quality studies and reviews on any factor that may influence the outcome of patients with venous disease. This journal provides authoritative information about all aspects of diseases of the veins including up to the minute reviews, original articles, and short reports on the latest treatment procedures and patient outcomes to help medical practitioners, allied health professionals and scientists stay up-to-date on developments. Print ISSN: 0268-3555

京公网安备 11010802042870号

Book学术文献互助群
群号：481959085