Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis

IF 1.1 Q4 VIROLOGY
S. Nag, Soma Sarkar, Debprasad Chattopadhyay, S. Bhattacharya, R. Biswas, M. Sengupta
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引用次数: 16

Abstract

Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without any herpetic lesion (non-HIV control) were taken as control. Serum was tested for IgM and IgG antibodies of both HSV-1 and HSV-2 by ELISA. The seroprevalence was compared among the three groups of study population, considering the demographic and socioeconomic parameters. The HSV-2 IgM was significantly higher (p < 0.005) in the HIV patient group (34.6%) than the HIV control (2.2%) and non-HIV control (2.2%) groups, whereas HSV-2 IgG seroprevalence was higher in both HIV patient (61.5%) and HIV control (57.8%) groups than the non-HIV control group (17.8%). The prevalence of HSV-2 was significantly higher in persons with multiple partners and in the reproductive age group. The overall seroprevalence of HSV-1 IgM was too low (<5%), whereas it was too high (about 90%) with HSV-1 IgG in all three study groups.
印度东部HIV合并感染者血清单纯疱疹病毒感染的患病率及危险因素分析
单纯疱疹病毒2型(HSV-2)是大多数生殖器疱疹的病因,而单纯疱疹病毒1型是口腔和面部病变的原因。在免疫功能低下的个体中,如艾滋病毒患者,免疫力受损导致更频繁的有症状和无症状的HSV感染。将临床诊断为HSV感染的HIV患者的52份血样作为病例,将HIV感染者(HIV对照组)和未感染且无疱疹性病变的患者(非HIV对照组)各45份血样作为对照。采用ELISA法检测血清中HSV-1和HSV-2的IgM和IgG抗体。考虑人口统计学和社会经济参数,比较三组研究人群的血清阳性率。HIV患者组HSV-2 IgM阳性率(34.6%)显著高于HIV对照组(2.2%)和非HIV对照组(2.2%),而HIV患者组(61.5%)和HIV对照组(57.8%)血清HSV-2 IgG阳性率均高于非HIV对照组(17.8%)。2型单纯疱疹病毒在有多个性伴侣和育龄人群中的流行率明显较高。在所有三个研究组中,HSV-1 IgM的总体血清阳性率过低(<5%),而HSV-1 IgG的总体血清阳性率过高(约90%)。
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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
23
审稿时长
22 weeks
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