Effect of Preemptive Flurbiprofen Axetil and Tramadol on Transurethral Resection of the Prostate under Spinal Anesthesia

Q2 Medicine
Jinguo Wang, Hongqin Li, Haichun Ma, Na Wang
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引用次数: 6

Abstract

Objective. To investigate the efficacy of preoperative intravenous flurbiprofen axetil and tramadol on spinal anesthesia for transurethral resection of the prostate (TURP). Methodology. In this prospective clinical study, we enrolled 60 patients undergoing TURP under spinal anesthesia with small-dose bupivacaine and sufentanil. Patients were randomly divided in two: group flurbiprofen axetil and tramadol (Group FT) intravenously received 1 mg/kg flurbiprofen axetil and 1 mg/kg tramadol 20 min prior to the surgical procedures and group control (Group C) was given normal saline. The characteristics of spinal anesthesia, blood pressure, heart rate, analgesic requirement, visual analogue scale (VAS), and overall satisfaction degree were collected. Results. Time to the first analgesic requirement was significantly longer in Group FT. Patients who needed postoperative analgesics were fewer in Group FT. VAS scores were lower in Group FT at postoperative time points of 1, 2, 6, and 12 h. The patients in Group FT were more satisfied than in Group C. Conclusions. Preoperative flurbiprofen axetil and tramadol can reduce and delay postoperative pain and then decrease analgesic consumption for TURP under spinal anesthesia without an increase of side effects.
氟比洛芬酯和曲马多在脊髓麻醉下经尿道前列腺切除术中的作用
目标。目的探讨经尿道前列腺电切术(TURP)术前静脉注射氟比洛芬酯和曲马多对脊髓麻醉的影响。方法。在这项前瞻性临床研究中,我们招募了60例在脊髓麻醉下使用小剂量布比卡因和舒芬太尼进行TURP的患者。将患者随机分为两组:氟比洛芬酯和曲马多组(FT组)在手术前20分钟静脉注射氟比洛芬酯和曲马多1 mg/kg,对照组(C组)给予生理盐水。收集脊髓麻醉特征、血压、心率、镇痛需求、视觉模拟评分(VAS)及总体满意度。结果。FT组到第一次需要镇痛药的时间明显更长。术后需要镇痛药的患者较少。FT组在术后1、2、6和12 h的VAS评分较低。FT组患者满意度高于c组。术前应用氟比洛芬酯和曲马多可减轻和延缓术后疼痛,从而减少脊髓麻醉下TURP的镇痛用量,且副作用不增加。
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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
自引率
0.00%
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