A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo.

IF 11.4 1区生物学 Q1 CELL BIOLOGY

Annual review of cell and developmental biology Pub Date : 2019-10-07 DOI:10.1146/annurev-cellbio-100818-125134

M. Pickett, Victor F. Naturale, J. Feldman

{"title":"A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo.","authors":"M. Pickett, Victor F. Naturale, J. Feldman","doi":"10.1146/annurev-cellbio-100818-125134","DOIUrl":null,"url":null,"abstract":"Polarization along an apico-basolateral axis is a hallmark of epithelial cells and is essential for their selective barrier and transporter functions, as well as for their ability to provide mechanical resiliency to organs. Loss of polarity along this axis perturbs development and is associated with a wide number of diseases. We describe three steps involved in polarization: symmetry breaking, polarity establishment, and polarity maintenance. While the proteins involved in these processes are highly conserved among epithelial tissues and species, the execution of these steps varies widely and is context dependent. We review both theoretical principles underlying these steps and recent work demonstrating how apico-basolateral polarity is established in vivo in different tissues, highlighting how developmental and physiological contexts play major roles in the execution of the epithelial polarity program. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"1 1","pages":""},"PeriodicalIF":11.4000,"publicationDate":"2019-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100818-125134","citationCount":"27","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of cell and developmental biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-cellbio-100818-125134","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 27

Abstract

Polarization along an apico-basolateral axis is a hallmark of epithelial cells and is essential for their selective barrier and transporter functions, as well as for their ability to provide mechanical resiliency to organs. Loss of polarity along this axis perturbs development and is associated with a wide number of diseases. We describe three steps involved in polarization: symmetry breaking, polarity establishment, and polarity maintenance. While the proteins involved in these processes are highly conserved among epithelial tissues and species, the execution of these steps varies widely and is context dependent. We review both theoretical principles underlying these steps and recent work demonstrating how apico-basolateral polarity is established in vivo in different tissues, highlighting how developmental and physiological contexts play major roles in the execution of the epithelial polarity program. Expected final online publication date for the Annual Review of Cell and Developmental Biology, Volume 35 is October 7, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

查看原文本刊更多论文

两极分化问题:体内尖-基底侧极化机制的多样性。

沿顶基底侧轴的极化是上皮细胞的特征，对其选择性屏障和转运功能以及为器官提供机械弹性的能力至关重要。沿这条轴的极性丧失会扰乱发育，并与许多疾病有关。我们描述了极化的三个步骤:对称性破坏、极性建立和极性维持。虽然参与这些过程的蛋白质在上皮组织和物种中高度保守，但这些步骤的执行差异很大，并且依赖于环境。我们回顾了这些步骤背后的理论原理和最近的研究成果，展示了顶基底外侧极性是如何在体内不同组织中建立的，强调了发育和生理环境在上皮极性程序的执行中发挥的主要作用。《细胞与发育生物学年度评论》第35卷的最终在线出版日期预计为2019年10月7日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annual review of cell and developmental biology 生物-发育生物学

CiteScore

19.50

自引率

0.00%

发文量

期刊介绍： The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.