Clinical correlates of quality of life in Tourette syndrome†

IF 7.4 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2010-11-10 DOI:10.1002/mds.23434

Clare M. Eddy BSc, PhD, Andrea E. Cavanna MD, PhD, Mariangela Gulisano MD, PhD, Antonella Agodi PhD, Martina Barchitta PhD, Paola Calì MD, Mary M. Robertson MBChB, MD, DSc (Med), DPM, FRCPCH, FRCP (UK), FRCPsych, Renata Rizzo MD, PhD

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引用次数: 112

Abstract

Tourette syndrome (TS) is a neurodevelopmental disorder involving tics, which is frequently accompanied by comorbid obsessive compulsive (OCD) or attention deficit hyperactivity disorder (ADHD). Individuals with TS often report poor quality of life (QoL) in comparison with the general population. This study investigated the clinical correlates of QoL in young people with TS using a self-report multidimensional QoL measure, and a range of clinical scales used to assess tic severity and the symptoms of anxiety, depression, OCD, ADHD and other emotional and behavioral symptoms. Symptoms of depression, OCD, and ADHD appeared to have a widespread negative impact on QoL, but poorer QoL was not associated with increased tic severity. Greater emotional and behavioral difficulties, including symptoms of OCD, were among the best predictors of poor QoL in young people with TS. © 2010 Movement Disorder Society

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图雷特综合征患者生活质量的临床相关因素

图雷特综合症(TS)是一种涉及抽搐的神经发育障碍，通常伴有共病强迫症(OCD)或注意缺陷多动障碍(ADHD)。与一般人群相比，患有TS的个体通常报告生活质量(QoL)较差。本研究采用自我报告多维生活质量量表，以及一系列用于评估抽动严重程度和焦虑、抑郁、强迫症、多动症等情绪和行为症状的临床量表，探讨了青少年TS患者生活质量的临床相关性。抑郁、强迫症和多动症的症状似乎对生活质量有广泛的负面影响，但生活质量较差与抽动严重程度增加无关。更大的情绪和行为困难，包括强迫症症状，是年轻TS患者生活质量差的最佳预测因素之一。©2010运动障碍学会

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.