Neural correlates of decreased impulsivity during delay discounting task after laparoscopic sleeve gastrectomy

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2023-05-19 DOI:10.1002/oby.23763

Wenchao Zhang, Guanya Li, Yang Hu, Jia Wang, Weibin Ji, Karen M. von Deneen, Juan Yu, Yu Han, Guangbin Cui, Peter Manza, Dardo Tomasi, Nora D. Volkow, Huaning Wang, Yongzhan Nie, Gang Ji, Gene-Jack Wang, Yi Zhang

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引用次数: 0

Abstract

Objective

The goal of this study was to investigate laparoscopic sleeve gastrectomy (LSG)-induced changes in choice impulsivity and the neural correlates in individuals with obesity (OB).

Methods

The study employed functional magnetic resonance imaging with a delay discounting task in 29 OB tested before and 1 month after LSG. Thirty participants with normal weight matched to OB with gender and age were recruited as the control group and underwent an identical functional magnetic resonance imaging scan. Alterations in activation and functional connectivity between pre- and post-LSG were investigated and compared with participants with normal weight.

Results

OB exhibited significantly reduced discounting rate after LSG. During the delay discounting task, hyperactivation in dorsolateral prefrontal cortex, right caudate, and dorsomedial prefrontal cortex decreased in OB after LSG. LSG additionally engaged compensatory effects through increased activation in bilateral posterior insula and functional connectivity between caudate and dorsomedial prefrontal cortex. Those changes were associated with decreased discounting rate and BMI as well as improved eating behaviors.

Conclusions

These findings indicate that decreased choice impulsivity following LSG was associated with the changes in regions involved in executive control, reward evaluation, interoception, and prospection. This study may provide neurophysiological support for the development of nonoperative treatments such as brain stimulation for individuals with obesity and overweight.

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腹腔镜袖胃切除术后延迟折扣任务中冲动性降低的神经相关研究

目的探讨腹腔镜下袖式胃切除术(LSG)对肥胖患者选择冲动及神经相关因素的影响。方法对29例OB患者在LSG前后1个月进行功能磁共振成像和延迟贴现任务研究。招募30名体重正常，性别和年龄与OB相匹配的参与者作为对照组，并进行相同的功能磁共振成像扫描。研究了lsg前后激活和功能连接的变化，并与体重正常的参与者进行了比较。结果经LSG治疗后，OB的折扣率明显降低。在延迟贴现任务中，LSG后OB的背外侧前额叶皮层、右尾状皮层和背内侧前额叶皮层的过度激活减少。LSG还通过增加双侧后岛的激活以及尾状和背内侧前额叶皮层之间的功能连接参与代偿作用。这些变化与折扣率和BMI的降低以及饮食习惯的改善有关。结论LSG后选择冲动的降低与执行控制、奖励评价、内感受和展望等区域的变化有关。该研究可能为发展非手术治疗如脑刺激治疗肥胖和超重个体提供神经生理学支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.