Pharmacokinetics of meloxicam in pre-ruminant calves after intravenous, oral, and subcutaneous administration

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Annemari Jokela, Alexandra Nyrhilä, Magdy Adam, Kati Salla, Marja Raekallio, Riikka Aho, Marianna Norring, Ann-Helena Hokkanen
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Abstract

Meloxicam is routinely used for pain alleviation in pre-ruminant calves during husbandry procedures. The pharmacokinetics of a single dose (0.5 mg/kg) of meloxicam was investigated after intravenous (IV), subcutaneous (SC), and oral (PO) administration in 30 pre-ruminant calves. Each group included 10 calves. Oral meloxicam was administered at least 1 h after feeding. Plasma samples were collected for up to 168 h, and the meloxicam concentration was analysed with liquid chromatography and mass spectrometry, followed by a noncompartmental pharmacokinetic analysis. The maximum meloxicam concentrations in plasma were 1.91 ± 0.27 μg/mL and 1.77 ± 0.16 μg/mL after SC and PO routes, respectively. The time of maximum concentration was 7.6 ± 2.8 h after SC and 10.0 ± 5.7 h after PO administration. The approximate bioavailability of meloxicam was 97% for SC and PO routes. The elimination half-lives were 79.2 ± 12.4, 84.6 ± 24.8, and 84.8 ± 22.3 h after IV, SC, and PO routes, respectively. The results suggest that the therapeutic meloxicam concentrations in plasma that are required for pain relief in other species, such as horses, may be maintained for several days following a single dose (0.5 mg/kg) administered IV, SC, or PO in calves.

Abstract Image

美洛昔康在反刍前小牛静脉、口服和皮下给药后的药代动力学。
在饲养过程中,美洛昔康通常用于缓解反刍前小牛的疼痛。单剂量(0.5 mg/kg)美洛昔康对30头反刍前小牛进行静脉(IV)、皮下(SC)和口服(PO)给药后的研究。每组包括10头小牛。口服美洛昔康至少1次 h。采集了多达168份血浆样本 h、 用液相色谱法和质谱法分析美洛昔康的浓度,然后进行非室药代动力学分析。美洛昔康在血浆中的最大浓度为1.91 ± 0.27 μg/mL和1.77 ± 0.16 μg/mL。最大浓度时间为7.6 ± 2.8 SC后h和10.0 ± 5.7 PO给药后h。对于SC和PO途径,美洛昔康的近似生物利用度为97%。消除半衰期为79.2 ± 12.4、84.6 ± 24.8和84.8 ± 22.3 分别在IV、SC和PO路线之后的h。研究结果表明,在单次给药后,其他物种(如马)的血浆中缓解疼痛所需的治疗性美洛昔康浓度可以维持几天(0.5 mg/kg)在小牛中给予IV、SC或PO。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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