Influence of phthalate and non-phthalate plasticizers on reproductive endocrine system-related gene expression profiles in Japanese medaka (Oryzias latipes).

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 Epub Date: 2023-11-10 DOI:10.1080/10934529.2023.2273690

Yoshifumi Horie, Dorcas Uaciquete

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引用次数: 0

Abstract

Plasticizers containing phthalates have the potential to alter endocrine function in vertebrates. While non-phthalate plasticizers were previously considered to be environmentally friendly and safe, our research team discovered that bis-(2-ethylhexyl) adipate (DEHA) and acetyl tributyl citrate (ATBC) disrupt thyroid hormones in Japanese medaka (Oryzias latipes). We assessed reproductive- and estrogen-responsive gene expression patterns in Japanese medaka to determine whether the phthalate plasticizers bis-(2-ethylhexyl) phthalate (DEHP, positive control) and the non-phthalate plasticizers DEHA and ATBC disrupt endocrine signaling. The results showed that the levels of choriogenin H (chgH) and vitellogenin (vtg) genes increased after exposure to DEHP and ATBC, suggesting that these plasticizers may have estrogenic activity. Exposure to DEHP and DEHA resulted in the upregulation of kisspeptin (kiss), gonadotropin-releasing hormone (gnrh), and follicle-stimulating hormone beta (fshβ) genes, suggesting that these plasticizers may interfere with reproductive function. To the best of our knowledge, this is the first study to demonstrate that the non-phthalate plasticizers DEHA and ATBC can disrupt reproduction-related hormonal activity in fish.

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邻苯二甲酸酯和非邻苯二酸酯增塑剂对日本青花生殖内分泌系统相关基因表达谱的影响。

含有邻苯二甲酸酯的增塑剂有可能改变脊椎动物的内分泌功能。虽然非邻苯二甲酸酯增塑剂以前被认为是环境友好和安全的，但我们的研究团队发现己二酸二（2-乙基己基）酯（DEHA）和乙酰柠檬酸三丁酯（ATBC）会破坏日本花（Oryzias latipes）的甲状腺激素。我们评估了日本花呢的生殖和雌激素反应基因表达模式，以确定邻苯二甲酸酯增塑剂邻苯二甲二（2-乙基己基）酯（DEHP，阳性对照）和非邻苯二酸酯增塑剂DEHA和ATBC是否破坏内分泌信号。结果表明，暴露于DEHP和ATBC后，绒毛膜生成素H（chgH）和卵黄生成素（vtg）基因水平升高，表明这些增塑剂可能具有雌激素活性。暴露于DEHP和DEHA导致kisspeptin（kiss）、促性腺激素释放激素（gnrh）和卵泡刺激素β（fshβ）基因上调，表明这些增塑剂可能干扰生殖功能。据我们所知，这是第一项证明非邻苯二甲酸酯类增塑剂DEHA和ATBC可以破坏鱼类生殖相关激素活性的研究。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.