Longer leukocyte telomere length increases cardiovascular mortality in type 2 diabetes patients 白细胞端粒长度增长会增加2型糖尿病患者的心血管死亡率

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2023-03-08 DOI:10.1111/1753-0407.13376

Ziwei Chen, Yao Shen, Jing He, Yang Shen, Weida Zhu, Xiaohui Wu, Mingbing Xiao

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引用次数: 2

Abstract

Aims

Leukocyte telomere length (LTL), as a biomarker of biological aging, is associated with the prevalence and complications of diabetes. This study aims to investigate the associations between LTL and all-cause and cause-specific mortality in patients with type 2 diabetes.

Methods

All participants with baseline LTL records were included from the National Health and Nutrition Examination Survey 1999–2002. Death status and its causes were ascertained for National Death Index based on International Classification of Diseases, Tenth Revision code. Cox proportional hazards regression models were established to estimate the hazard ratios (HRs) of LTL associating with all-cause and cause-specific mortality.

Results

The study enrolled 804 diabetic patients with the mean follow-up of 14.9 ± 2.59 years. There were 367 (45.6%) all-cause deaths, 80 (10.0%) cardiovascular deaths, and 42 (5.2%) cancer-related deaths. Longer LTL was associated with reduced all-cause mortality, whereas this association disappeared after adjusting for other variables. Compared with the lowest tertiles of LTL, the multivariable-adjusted hazard ratio of cardiovascular mortality was 2.11 (95% confidence interval [CI] 1.31–3.39; p < .05) in the highest tertiles. In terms of cancer mortality, the highest tertile was negatively correlated with the risk of cancer mortality (HR 0.58 [95% CI 0.37, 0.91], p < .05).

Conclusion

In conclusion, LTL was independently associated with the risk of cardiovascular mortality in patients with type 2 diabetes and was negatively correlated with the risk of cancer mortality. Telomere length may be a predictor of cardiovascular mortality in diabetes.

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Longer leukocyte telomere length increases cardiovascular mortality in type 2 diabetes patients 白细胞端粒长度增长会增加2型糖尿病患者的心血管死亡率

目的白细胞端粒长度(LTL)作为生物衰老的标志物，与糖尿病的患病率和并发症有关。本研究旨在探讨LTL与2型糖尿病患者全因死亡率和病因特异性死亡率之间的关系。方法选取1999-2002年全国健康与营养调查中有LTL基线记录的所有参与者。根据《国际疾病分类第十次修订代码》确定国家死亡指数的死亡状态及其原因。建立Cox比例风险回归模型，估计LTL与全因死亡率和病因特异性死亡率相关的风险比(hr)。结果共纳入804例糖尿病患者，平均随访时间14.9±2.59年。全因死亡367例(45.6%)，心血管死亡80例(10.0%)，癌症相关死亡42例(5.2%)。较长的生命周期与全因死亡率降低相关，而在调整其他变量后，这种关联消失。与最低三分位数的LTL相比，多变量校正的心血管死亡率风险比为2.11(95%可信区间[CI] 1.31-3.39;P < .05)。在癌症死亡率方面，最高分值与癌症死亡率风险呈负相关(HR 0.58 [95% CI 0.37, 0.91]， p < 0.05)。综上所述，LTL与2型糖尿病患者心血管死亡风险独立相关，与癌症死亡风险负相关。端粒长度可能是糖尿病心血管死亡率的一个预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.