Sustainable Drug Release Using Nanoparticle Encapsulated Microneedles

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2022-05-29 DOI:10.1002/asia.202200333

Sin Jin Oh, Prof. Jae Hwan Jung

引用次数: 4

Abstract

Microneedle (MN) is a minimally invasive drug delivery method that is directly inserted into the skin without pain to improve the efficiency of transdermal administration and is a drug delivery system used to treat various diseases. Furthermore, nanoparticle (NP)-based drug delivery methods suggest therapeutic strategies to improve drug solubility and increase drug delivery efficiency. Therefore, the drug delivery system in which NPs and MNs are integrated is a promising alternative to the existing delivery methods of poorly soluble and hydrophobic drugs and nucleic acid therapeutics. This system can increase the solubility of drugs and biocompatibility in the body and improve the therapeutic efficacy with sustained drug release. In this review, we investigated recent studies of NPs designed for drug delivery, sustained-release drug delivery MNs based on these NPs, and the applications for clinical treatments.

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利用纳米颗粒封装的微针可持续释放药物

微针(MN)是一种微创给药方式，直接插入皮肤，无痛，提高经皮给药效率，是一种用于治疗各种疾病的给药系统。此外，基于纳米颗粒(NP)的药物递送方法提出了改善药物溶解度和提高药物递送效率的治疗策略。因此，整合NPs和MNs的药物传递系统是现有的难溶性和疏水药物和核酸治疗药物传递方法的一个有希望的替代方案。该系统能提高药物在体内的溶解度和生物相容性，提高药物的缓释疗效。在这篇综述中，我们综述了用于给药的NPs，基于这些NPs的缓释给药MNs的最新研究，以及在临床治疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).