Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2022-11-04 DOI:10.1111/acps.13517

Lisanne Schrijver, Thalia K. Robakis, Astrid M. Kamperman, Hilmar Bijma, Adriaan Honig, Inge L. van Kamp, Witte J. G. Hoogendijk, Veerle Bergink, Eline M. P. Poels

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引用次数: 0

Abstract

Objective

Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.

Methods

We performed a cross-sectional neurodevelopmental assessment of 91 children aged 6–14 years whose mothers had severe mental illness and were either exposed or unexposed to antipsychotic medication during pregnancy. Neurodevelopmental outcomes were assessed using validated neurodevelopmental assessment instruments to examine the child's IQ and global cognitive functioning, and the presence of any psychiatric disorders and/or learning problems in the child was assessed by parental report.

Results

No statistically significant associations were found between antipsychotic exposure during pregnancy and either adverse neurodevelopmental outcomes (IQ, neuropsychological function), likelihood of psychiatric diagnosis, or learning problems based on parental report. Analyses were likely limited in power to detect subtler differences in neurodevelopmental functioning because of small sample size and heterogeneity of the sample.

Conclusions

In this exploratory cohort study, intrauterine exposure to antipsychotics was not associated with any adverse effect on IQ or neurodevelopmental functioning in a cohort of school-aged children (6–14 years).

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宫内接触抗精神病药物后学龄儿童的神经发育

目的抗精神病药物越来越多地用于妊娠，但对儿童长期发育的潜在影响知之甚少。在这项研究中，我们调查了产前抗精神病药物暴露对学龄儿童神经发育功能的影响。方法我们对91名6-14岁的儿童进行了横断面神经发育评估，这些儿童的母亲患有严重的精神疾病，在怀孕期间暴露或未暴露于抗精神病药物。使用经过验证的神经发育评估工具评估儿童的智商和整体认知功能，并通过父母报告评估儿童是否存在精神障碍和/或学习问题。结果妊娠期抗精神病药物暴露与不良神经发育结局(智商、神经心理功能)、精神病诊断的可能性或基于父母报告的学习问题之间没有统计学上的显著关联。由于样本量小和样本的异质性，分析可能在检测神经发育功能的细微差异方面的能力有限。结论:在这项探索性队列研究中，在一组学龄儿童(6-14岁)中，宫内接触抗精神病药物与智商或神经发育功能的任何不良影响无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.