Current State of [Fe]-Hydrogenase and Its Biomimetic Models

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2022-07-03 DOI:10.1002/chem.202201499

Chao Wang, Zhenli Lai, Prof.?Dr. Gangfeng Huang, Prof.?Dr. Hui-Jie Pan

引用次数: 7

Abstract

[Fe]-hydrogenase, the third type of natural hydrogenase, is capable to heterolytically activate hydrogen molecule and transfer the resulting hydride to an unsaturated substrate, making it a promising hydrogenation catalyst. Over the last three decades, fruitful results on this enzyme have been achieved. In this review, we have summarized the major progresses about this enzyme including its structural characterisation, catalytic mechanism, cofactor biosynthesis, mimetic model development as well as artificial enzymes construction. In the meanwhile, challenges and opportunities of this enzyme and its mimetic systems in the application of synthetic chemistry and others are discussed.

Abstract Image

查看原文本刊更多论文

[Fe]-氢化酶的研究现状及其仿生模型

[Fe]-加氢酶是第三类天然加氢酶，它能异解激活氢分子，并将生成的氢化物转移到不饱和底物上，是一种很有前途的加氢催化剂。在过去的三十年里，对这种酶的研究取得了丰硕的成果。本文综述了该酶的结构表征、催化机理、辅助因子的生物合成、模拟模型的建立以及人工酶的构建等方面的研究进展。同时，讨论了该酶及其模拟体系在合成化学等方面的应用所面临的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.