Synthesis of MoSe2/CoSe2 Nanosheets for NIR-Enhanced Chemodynamic Therapy via Synergistic In-Situ H2O2 Production and Activation

Abstract

Currently, the limited intratumoral H₂O₂ level restricts the development of chemodynamic therapy (CDT). Herein, MoSe₂/CoSe₂@PEG nanosheets are prepared to reveal NIR-photocatalytic H₂O₂ generation to insure the intracellular H₂O₂ supplement. The formation mechanism is investigated, showing the dissolved O₂ and photo-excited electrons to determine H₂O₂ production via sequential single-electron transfer process. The experimental data and density functional theory calculation further display their typical-II heterostructure, which possesses the effective charge separation and nearly four times H₂O₂ generation than MoSe₂@PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in-situ H₂O₂ activation and ·OH generation. And, the O₂ production derived from catalase-mimic activity not only relieves hypoxia but also offers the source for H₂O₂ production. Because of the decreased resistance for charge transfer, MoSe₂/CoSe₂@PEGs also reveal more than three times enzyme-activity for MoSe₂@PEG. With the narrow band gap and high NIR-harvest, MoSe₂/CoSe₂@PEG exhibits the great photothermal converting ability (62.5%). MoSe₂/CoSe₂@PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.