Cell Therapy Strategies to Combat Immunosenescence

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Organogenesis Pub Date : 2015-10-02 DOI:10.1080/15476278.2015.1120046

E. Stahl, B. Brown

引用次数: 55

Abstract

abstract Declining function of the immune system, termed “immunosenescence,” leads to a higher incidence of infection, cancer, and autoimmune disease related mortalities in the elderly population.1 Increasing interest in the field of immunosenescence is well-timed, as 20% of the United States population is expected to surpass the age of 65 by the year 2030.2 Our current understanding of immunosenescence involves a shift in function of both adaptive and innate immune cells, leading to a reduced capacity to recognize new antigens and widespread chronic inflammation. The present review focuses on changes that occur in haematopoietic stem cells, macrophages, and T-cells using knowledge gained from both rodent and human studies. The review will discuss emerging strategies to combat immunosenescence, focusing on cellular and genetic therapies, including bone marrow transplantation and genetic reprogramming. A better understanding of the mechanisms and implications of immunosenescence will be necessary to combat age-related mortalities in the future.

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对抗免疫衰老的细胞治疗策略

免疫系统功能的下降，被称为“免疫衰老”，导致老年人感染、癌症和自身免疫性疾病相关死亡率的升高人们对免疫衰老领域的兴趣日益浓厚，因为预计到2030年，20%的美国人口将超过65岁。我们目前对免疫衰老的理解包括适应性和先天免疫细胞功能的改变，导致识别新抗原的能力下降和广泛的慢性炎症。目前的综述主要集中在造血干细胞、巨噬细胞和t细胞中发生的变化，利用从啮齿动物和人类研究中获得的知识。这篇综述将讨论对抗免疫衰老的新策略，重点是细胞和基因治疗，包括骨髓移植和基因重编程。更好地了解免疫衰老的机制和影响将是必要的，以对抗年龄相关的死亡在未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.